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Assembly of the 30S ribosomal subunit in vitro and in cells - (Henry Stewart Talks)

Bacterial ribosome biogenesis; The Nomura assembly map; RNA folding and protein binding; Single molecule fluorescence; The basis for cooperative assembly; Isotope pulse chase experiments; Protein binding kinetics; The assembly landscape

Assessing significance in genome-wide studies - (Henry Stewart Talks)

"Hypothesis testing; Ruling out artefactual associations; Asymptotic P values and problems with interpretation; Multiple testing and Bonferroni corrections; Permutation, pointwise and genomewise significance; Bayes factors"

Assessment of Obesity and Classification of Patients: Historical Perspectives and Current Practice - (Henry Stewart Talks)

"Obesity is not a new problem; Palaeolithic times: Venus of Willendorf; Neolithic times: Venus of Catalhoyuk; MesoAmerican times: Mayan figurine; Historical times to 1500AD: Mesopotamian, Egyptian, Chinese and Tibetan, Indian and Greco-Roman"

Atomistic Simulations: Simulating the Interatomic Interactions - (Henry Stewart Talks)

Protein folding and disease; Folding kinetics can have a biological impact; Why use physical simulation?; Primary challenges; Possible models; Building atomistic models; Modern force fields; Ways to treat water; Implicit solvent models

ATP-Dependent Chromatin Remodeling Machines - (Henry Stewart Talks)

ATP-dependent chromatin remodeling complexes; ATP hydrolysis and nucleosome dynamics; Mechanistic action; Cellular function

Atypical Parkinsonian Syndromes - (Henry Stewart Talks)

Types of atypical parkinsonian syndromes; Descriptive epidemiology; Clinical features; Cognitive and neurobehavioural aspects; Pathology and aetiology; Natural history; Structural and functional investigations; Clinical management

Audience Questions about Evolutionary Medicine - (Henry Stewart Talks)

Certain questions always come up; They reveal deep interest in the evolutionary medicine and substantial ignorance about evolution; Answering them fills some gaps in the rest of the lecture series; The future of Darwinian Medicine

Audio Digest

The AudioDigest website provides access to mp3 files of their monthly subscription programs. The library also purchases these programs on Audio-CDs for you to borrow. The library has a single user subscription to the audio files. The library’s password can be found on the “Get the Passwords” page for UCHC IP addresses. http://library.uchc.edu/mdconsult/ejnlpswd.html. Here is the instruction on how to use the Audio Digest.

Auto-antibodies as Predictors of Autoimmune Disease - (Henry Stewart Talks)

Natural history of autoimmune diseases; Predictive value of autoantibodies; Anti-dsDNA antibodies and SLE; Anti-nuclear antibodies and SLE; Anti-Ro/La antibodies and Sjogren's syndrome; Rheumatoid factor and anti-CCP antibodies in rheumatoid arthritis

Autoimmune Features in Celiac Disease - (Henry Stewart Talks)

"Celiac disease definition, epidemiology and the clinical picture; Genetic and environmental factors; Associated diseases; Extra intestinal manifestations; Intestinal pathology; Specific and associated autoantibodies; T cell clonality"

Autoimmunity and Atherosclerosis - (Henry Stewart Talks)

"Autoimmunity; High risk of atherosclerosis in autoimmune diseases, especially systemic lupus erythematosus (SLE); Antiphospholipid antibodies and atherosclerosis; Association and risk factors for atherosclerosis and cardiovascular disease in SLE"

Autophagic Cell Death - (Henry Stewart Talks)

Morphological forms of cell death; Why is autophagy of interest to cell death researchers?; What is autophagy?; Discovery of autophagy genes; How is autophagy regulated?; Class I PI3K signalling and Class III PI3K signalling

Axon guidance in Drosophila - (Henry Stewart Talks)

How axons grow; The growth cone; The Drosophila nervous system; Receptors and ligands involved in axon guidance events; Attractive and repulsive receptor signaling; Integration of receptor signals in the growth cone

B Lymphocytes on the Frontline of Autoimmunity - (Henry Stewart Talks)

Subpopulations of B cells; CD5-positive B cells; Marginal zone B cells; Follicular B cells; Pathogenic B cells; Cytokine-producing B cells; B cells and tolerance; BCR co-receptor molecules; Lipid rafts; BAFF in autoimmunity; The CD5 molecule in tolerance

Bacteria and Virus Evolution: A Model for the Study of Natural Selection - (Henry Stewart Talks)

Experimental evolution; Classic experiments using bacteria and viruses; Evolution of antibiotic resistance in bacteria; Evolution of higher and lower virulence in pathogens; Evolution of pathogen emergence

Bacterial extrachromosomal elements: role in chemical detoxification and potential cancer therapy - (Henry Stewart Talks)

"Examples of degradative plasmids; Xylene and toluene degradation by TOL plasmids; The chloro-catechol orthocleavage pathway; Catabolic pathways/genes in 2,4-D degradation; Chemostatic evolution of 2,4,5-T degradative genes"

Basic anatomy, physiology and pathophysiology of the cerebral circulation for the physician - (Henry Stewart Talks)

Anatomy of the cerebral arteries and veins; Main arterial territories; Physiological regulation of cerebral blood flow; Autoregulation of cerebral blood flow in physiological and pathological conditions

Basic Studies of Protein Folding and Stability: The Folding of Related Protein Families - (Henry Stewart Talks)

Basics of protein folding studies: protein stability (thermodynamics) and protein folding kinetics; Shape and interpretation of simple chevron plots

Bates' Guide to Physical Examination

Clips of this "streaming video" version demonstrate technique while audio content describes the procedures and rationales. To view videos, your computer requires Windows Media Player version 9 or higher, 56 kbs modem or higher speed broadband connection to the Internet, audio speakers or headphones and use IE Browser.

Bayesian Approaches for Modelling Complex Metabolic Pathways - (Henry Stewart Talks)

Case study: asthma; Multiple environmental agents; Polygenic factors; Standard approaches: contingency tables and logistic regression methods; Latest approaches: Bayesian model averaging and pharmacokinetic modelling; Case study: colorectal cancer

Bayesian principles - (Henry Stewart Talks)

Introduction to the Bayesian approach to statistics; The Bayesian method is presented and illustrated with an example in health; Bayesian approach is contrasted to the more familiar frequentist approach

Bcl-2 Family - (Henry Stewart Talks)

Apoptosis; Discovery of Bcl-2; Cell death in worms; Evolutionarily conserved pathways to cell death; How cell death initiates; BH3-only proteins; Control of BH3- only proteins; Promiscuous and selective BH3-only proteins

Beta-Globin Locus - (Henry Stewart Talks)

"Transcription of beta-globin family of genes; Regulation of gene expression during human development; Locus control region (LCR); DNase I hypersensitive sites in chromatin; Transcription factors including GATA-1, EKLF and NF-E2"

Bevacizumab: the first FDA-approved angiogenesis inhibitor in the treatment of non-small cell lung cancer - (Henry Stewart Talks)

Lung cancer incidence; Survival by treatment group; Selected trials of novel agents + chemotherapy; Bevacizumab; Vascular Endothelial Growth Factor (VEGF); Principles of angiogenesis; Bevacizumab in NSCLC: not for everybody

Biodefense Challenges - (Henry Stewart Talks)

"Viruses as bioterrorism or biowarfare threats; Smallpox virus and monkeypox virus; Equine encephalitis viruses: Venezuelan, eastern and western equine encephalitis viruses; Ebola and Marburg viruses; Rift Valley fever virus; Genetically engineered viruses"

Bioethics & Politics of Human Embryonic Stem Cell Science in the EU's 6th Framework Programme - (Henry Stewart Talks)

Cultural politics and bioethics; Regulatory options in human ESC science; National differences; Ethical debates in the European Parliament; Conflict over the human embryo; Politicians versus experts; The Human Tissues Directive

Biogenesis of E. coli inner membrane proteins - (Henry Stewart Talks)

SRP-mediated targeting to the inner membrane; Structure and function of the Sec-translocon in membrane insertion; Role of YidC as an insertase and membrane chaperone

Biogenesis of Mitochondria in Cancer - (Henry Stewart Talks)

"Mitochondria in cancer biology: energetic metabolism of the cancer cell; Otto Warburg and the Pasteur Effect; The bioenergetic signature of human cancers; Applicability of the bioenergetic signature in the clinics: colon, lung and breast cancer"

Bioinformatics Tools in Conservation Biology - (Henry Stewart Talks)

Conservation biology and genetics; Working with DNA sequences; Statistical tools for measuring genetic diversity; Genetic diversity and conservation: case studies; Phylogenetic tools for assessing genetic diversity; Phylogenetics and conservation

Biology and Pathobiology of von Willebrand Factor - (Henry Stewart Talks)

"Primary hemostasis; von Willebrand factor biochemistry and cell biology; von Willebrand disease diagnostic criteria; Molecular genetic pathology of type 3 vWD; Molecular genetic pathology of type 2A, 2B, 2M and 2N vWD; Mutational spectrum of type 1 vWD"

Biomarkers and Surrogate Endpoints in Randomized Clinical Trials - (Henry Stewart Talks)

"Definitions of biomarker, clinical endpoint, prognostic biomarker, predictive biomarker, and surrogate endpoint; Validation of prognostic, predictive and surrogate biomarker; Response as a surrogate endpoint for survival in advanced colorectal cancer"

Biomarkers in oncology: overview - (Henry Stewart Talks)

Tumor biomarkers; Role of tumor biomarkers in cancer screening; Aiding cancer diagnosis; Determining prognosis; Therapy prediction; Post-operative surveillance; Monitoring therapy in advanced disease

Biomarkers of Exposure - (Henry Stewart Talks)

"Biomarkers as indicators of exposure, adverse effects or susceptibility for an individual; Methods of exposure: inhalation, ingestion or skin absorption; Toxicokinetics as a guide to understanding biomarker behaviour; Calibration of biomarkers"

Biomimetic Catalysis - (Henry Stewart Talks)

"Biomimetic catalysis; Imitating enzymes for improved chemistry; Using geometric control in a catalyst-substrate complex; Mimics of cytochrome P-450, and of transaminase enzymes; High rate accelerations and high selectivities"

Bioorganic studies of vision - (Henry Stewart Talks)

Visual pigments; Visual chromophores; Activation of Rh and beta-AR; Retinal / vitamin A cycle; Selective capture of retinoid binding proteins; Photocrosslinking of chromophore to Rh; Tracking the chromophore / opsin interaction; Rhodopsin photocycle

Blood-brain barrier and brain tumors - (Henry Stewart Talks)

The blood-brain barrier (BBB); Brain tumors/glioblastoma multiforme; Pathobiology; Therapeutic option with chemotherapy; Targeted therapies; Circumvention of the BBB; Drug transporters; Preclinical models

Blood-brain barrier and CNS drug development - (Henry Stewart Talks)

Restrictive nature of the blood-brain barrier; Non-vascular routes for brain drug delivery; Vascular routes for brain drug delivery; Concept of Trojan horses; Discovery of novel receptor-mediated transcytosis routes across the blood-brain barrier

Blood-brain barrier in health and disease - (Henry Stewart Talks)

The blood-brain barrier is not a static barrier; The blood-brain barrier does inhibit drug delivery to the brain; The blood-brain barrier is at the level of the endothelial cell cytoarchitecture that line all cerebral blood vessels in the brain

Blood-brain barrier in multiple sclerosis - (Henry Stewart Talks)

Multiple sclerosis; Inflammatory demyelinating disease of the central nervous system; Etiology; Diagnosis; Magnetic resonance imaging; Current and novel therapies; Pathology; Blood-brain barrier damage; Experimental allergic encephalomyelitis

Blood-cerebrospinal fluid transport interface: choroid plexus - (Henry Stewart Talks)

"Choroid plexus; Formation of CSF; Permeability of blood; CSF barrier vs. blood-brain barrier; Choroidal secretion of peptides, growth factors and regulatory proteins; Homeostasis and bulk flow of extracellular fluid in the CNS"

Body composition - (Henry Stewart Talks)

Clinical applications; Historical overview; Five level model; Chronology of method development; Relationship to energy balance and outcome; Atomic level; Molecular level; Hydrodensitometry; Hydrometry; 3-compartment model; Photon Absorptiometry

Bone Marrow Therapy for Cardiac Infarct - (Henry Stewart Talks)

Heart failure: the problem; Reasons for increased heart failure; Current medical treatment of Congestive Heart Failure with systolic dysfunction; Stem cells in the future treatment of heart failure; Stem cell reservoirs

Bovine Leukemia Virus - (Henry Stewart Talks)

Viral replication of bovine leukemia virus; Transmission and pathogenesis in natural and experimental hosts; Dynamics of cell accumulation; Novel therapeutic approach

Brain-to-blood efflux transport of endogenous compounds and its analogue drug at the blood-brain barrier - (Henry Stewart Talks)

"The blood-brain barrier is not just a static wall, but "a cerebral clearance organ"; The BBB multiple efflux transporters play a part in CNS detoxification by pumping out endogenous compounds from the brain; Neurotransmitters; Neuromodulators"

Bunyaviruses - (Henry Stewart Talks)

Classification of bunyaviruses; Diseases caused by bunyaviruses; Natural history of bunyaviruses; Bunyavirus evolution; Bunyavirus replication; Bunyavirus reverse genetics; Bunyaviruses and the host innate immune response

Calcium Alterations in Familial Alzheimer's Disease (FAD) - (Henry Stewart Talks)

Introduction to Alzheimer's disease; Morphological and functional features; Genetic studies; Presenilin functions and calcium homeostasis; Calcium dyshomeostasis and FAD; Modulatory role of presenilin on IP3-evoked Calcium release

Calcium and the Regulation of Small GTPases - (Henry Stewart Talks)

"Introduction to small GTPases; Ras as a GTPase subfamily; Molecular entities, Ras GEFs and Ras GAPs, that couple Calcium to Ras activation; Temporal aspects of Calcium coupling to Ras activation"

Calcium and Transcription: Coupling - (Henry Stewart Talks)

"Calcium sources; Calcium-regulated transcription factors: Calcium/cAMP response element binding protein (CREB), nuclear factor of activated T-cells (NFAT) and serum response factor (SRF); Calcium signaling cascades; Calcium and cell differentiation"

Calcium Dynamics Between Mitochondria and the Endoplasmic Reticulum - (Henry Stewart Talks)

3D structure of the endoplasmic reticulum and mitochondria; Techniques to measure organelle calcium; Mitochondrial functions; Principles of mitochondrial calcium signaling; Functional coupling of the endoplasmic reticulum and the mitochondria

Calcium Efflux and Calcium Signals - (Henry Stewart Talks)

Introduction to [Calcium]c oscillations; Involvement of Calcium fluxes in [Calcium]c oscillations; Plasma membrane Calcium efflux; Impact of Calcium efflux inhibition on [Calcium]c oscillations; Mini-glucagon as a physiological Calcium efflux inhibitor