E-Media

Browse Database Titles

ALL   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z   Others

Symbols:
- UCHC Access (Proxy Needed For Off-Campus Access)
- Free Access

Calcium Alterations in Familial Alzheimer's Disease (FAD) - (Henry Stewart Talks)

Introduction to Alzheimer's disease; Morphological and functional features; Genetic studies; Presenilin functions and calcium homeostasis; Calcium dyshomeostasis and FAD; Modulatory role of presenilin on IP3-evoked Calcium release

Calcium and the Regulation of Small GTPases - (Henry Stewart Talks)

"Introduction to small GTPases; Ras as a GTPase subfamily; Molecular entities, Ras GEFs and Ras GAPs, that couple Calcium to Ras activation; Temporal aspects of Calcium coupling to Ras activation"

Calcium and Transcription: Coupling - (Henry Stewart Talks)

"Calcium sources; Calcium-regulated transcription factors: Calcium/cAMP response element binding protein (CREB), nuclear factor of activated T-cells (NFAT) and serum response factor (SRF); Calcium signaling cascades; Calcium and cell differentiation"

Calcium Dynamics Between Mitochondria and the Endoplasmic Reticulum - (Henry Stewart Talks)

3D structure of the endoplasmic reticulum and mitochondria; Techniques to measure organelle calcium; Mitochondrial functions; Principles of mitochondrial calcium signaling; Functional coupling of the endoplasmic reticulum and the mitochondria

Calcium Efflux and Calcium Signals - (Henry Stewart Talks)

Introduction to [Calcium]c oscillations; Involvement of Calcium fluxes in [Calcium]c oscillations; Plasma membrane Calcium efflux; Impact of Calcium efflux inhibition on [Calcium]c oscillations; Mini-glucagon as a physiological Calcium efflux inhibitor

Calcium Saga: A Matter of Life and Death - (Henry Stewart Talks)

Calcium and cytotoxicity; Indicator dyes for calcium detection; Alteration of thiol and calcium homeostasis causes cell death; Oxidative stress and thiol modification impair calcium storage and extrusion; Calcium ATPase

Calcium Signaling and Mitochondrial Function - (Henry Stewart Talks)

The calcium uniporter; Mitochondrial calcium efflux pathways; Steady state and net uptake; The regulation of cytoplasmic calcium by mitochondria; The role of phosphate and the matrix calcium phosphate complex; Uniporter kinetics; The set-point concept

Calcium, Calmodulin and Calcineurin - (Henry Stewart Talks)

Calmodulin is highly conserved; Calmodulin structure; EF hand proteins; Calcium binding; Calmodulin targets; Mechanism of calmodulin action; Calmodulin-dependent protein kinases; Calmodulin dependent protein kinase II autonomy

Calcium-Regulated Adenylyl Cyclases and Cyclic AMP Compartmentalization - (Henry Stewart Talks)

"Calcium-entry; Elements of the compartment: adenylyl cyclases, lipid rafts, PP2A, NHE1, calmodulin and PDE; cAMP kinetics within the compartment in single cells: role of PDE4, PKA and AKAPs; cAMP oscillations"

Can Obesity be Prevented in the Current Obesogenic Environment? - (Henry Stewart Talks)

"Drivers of the obesity epidemic; Obesogenic environments; Lessons learned from other epidemics; Addressing "hosts", "vectors" and "environments"; Whole-of-community intervention programs"

Can we prevent type I diabetes? - (Henry Stewart Talks)

Type 1 diabetes is an autoimmune disease characterized by an immune destruction of the insulin producing beta-cells in the islets of Langerhans of the pancreas

Cancer pain and related symptoms: an overview - (Henry Stewart Talks)

Scope of the problem; Consequences of unrelieved cancer pain; Prevalence of cancer pain; Common cancer pain syndromes; Special populations; Barriers to cancer pain relief; Who develops chronic cancer pain

Cancer pain control: an evidence-based approach - (Henry Stewart Talks)

Importance of cancer pain control; Assessment and sources of cancer pain; Selecting agents according to pain mechanism; The WHO ladder; Nonopioids and adjuvants; Opioids; Side effects; Neuraxial drug delivery; Nondrug modalities

Capacitative (Store-Operated) Calcium Entry - (Henry Stewart Talks)

The concept of capacitative or store-operated calcium entry; Icrac; Pharmacology of store-operated entry; Theories of activation mechanisms; CIF; Stim1; TRP channels

Capillaroscopy in Autoimmune Rheumatic Diseases - (Henry Stewart Talks)

Materials and methods for the correct employment of the video capillaroscopy; The Raynaud's phenomenon and the role of capillaroscopy; The scleroderma pattern today; Scleroderma pattern and pathophysiological significance

Cardiovascular diseases: from epidemiology to nutritional interventions - (Henry Stewart Talks)

"Dietary treatment; small overview of the process of atherosclerosis; effects of dietary fat and cholesterol on risk factors; the influence of whole grains, dietary pattern and alcohol; the role of sodium; the importance of fruits and vegetables"

Cardiovascular risk factors - (Henry Stewart Talks)

Cardiovascular disease burden; Atherosclerosis as a cause of CVD; Non-modifiable and modifiable risk factors for CVD; Dyslipidemia and CVD risk; Apoproteins as CVD risk predictors

Carotenoid Functions and Other Isoprenoids in Plants - (Henry Stewart Talks)

Carotenoids in the diet; Vision; Isoprenoids to carotenoid biosynthesis; Photosynthetic apparatus; Requirement of vital carotenoids; Eco-physiology; Light harvesting carotenoids; Bioengineering of dietary additives; Beta-carotene and ketocarotenoids

Carotid endarterectomy, angioplasty and stenting - (Henry Stewart Talks)

Symptoms and signs of carotid stenosis; Imaging features; Indications for carotid endarterectomy for symptomatic stenosis; Indications for carotid endarterectomy for asymptomatic stenosis; Are angioplasty and stenting safe and effective alternatives?

Cartilage Stem Cells: Tools for Joint Repair? - (Henry Stewart Talks)

Cartilage repair; Cartilage progenitor isolation and characterization; Human articular cartilage progenitors; The role of Delta/Notch signalling in progenitor proliferation

Caspase Inhibitors in Drug Discovery - (Henry Stewart Talks)

Apoptotic caspases; Inflammatory caspases; Validation of caspase involvement in disease; Animal models; Rheumatoid arthritis; Liver degeneration; Small molecule drug discovery; Inhibitor specificity; Reversible and irreversible binding inhibitors

Caspases - (Henry Stewart Talks)

What makes apoptotic cells alike?; What are caspases?; From the worm to humans; What is special about proteases?; What do blood clotting and apoptosis have in common?; How do caspases disassemble a cell?; How do you find out if caspases are active?

Catalytic cycle of cytochrome P450s - (Henry Stewart Talks)

Catalytic cycle of cytochrome P450s; Substrate and oxygen binding; Key electron and proton transfers; Dioxygen cleavage; Formation of 'activated oxygen' hydroxylating species; Structure and electron transfer properties of NADPH-cytochrome P450 reductase

Catastrophic Antiphospholipid Syndrome and the Microangiopathic Antiphospholipid Syndrome - (Henry Stewart Talks)

"Description of the antiphospholipid syndrome (APS); Primary, secondary and intermediate syndromes; Thrombotic and non-thrombotic manifestations of the APS; Beta 2 glycoprotein 1; Relationship of APS to CAPS; Clinical manifestations of CAPS"

Cathepsin K in Bone and Joint Diseases - (Henry Stewart Talks)

Cysteine proteases; Cathepsin family; Expression of cathepsins and their activity; Collagen degradation; Pycnodysostosis; Cathepsin K in osteoporosis; Cathepsin K in arthritis; Mouse model of arthritis

CD20 Antibodies in the Targeting of B-Cell Malignancies and Autoimmunity - (Henry Stewart Talks)

Antibody targeting of B-cell malignancies and autoimmunity; CD20 antibody immunotherapy; CD20 structure and function; Antibody-dependent cellular cytotoxicity; Complement-dependent cytotoxicity; Mouse models of CD20 immunotherapy

CD44 Genetic Deletion Enhances and CD44 Antibody Targeting Attenuates Autoimmune Inflammation - (Henry Stewart Talks)

CD44 and RHAMM (receptor for hyaluronan-mediated motility) are cell adhesion and cell homing receptors; Cell migration; Generation of different CD44 isoforms; RHAMM also supports cell motility and is engaged in intracellular signalling

Celiac plexus block - (Henry Stewart Talks)

Anatomy; Demographics of pancreatic cancer pain; US cancer deaths; Relative survival; Pancreatic cancer risk factors; Pancreatic cancer pain; Retrocrural anatomy and pancreatic cancer; Celiac Technique

Cell signaling by Vitamin E - (Henry Stewart Talks)

"Vitamin E or tocopherol's physiological molecular mechanism helps to understand protection against disease; Not an antioxidant or free radical quencher, they perform cell signaling by affecting protein phosphorylation"

Cell Surface Glycoproteins on Cells of the Immune System - (Henry Stewart Talks)

Lymphocyte cell surface; Membrane proteins; Identification of interactions; Protein microarrays; Monoclonal antibodies; Recombinant proteins; Characterization of interactions at a molecular level; Reaction kinetics; Protein structure

Cellular composition of the blood-brain barrier - (Henry Stewart Talks)

Sites of CNS barriers; Neurovascular unit; Blood-brain barrier (BBB) at brain capillary endothelium; Functions of BBB; Tight junctions; Pathways across the BBB; BBB biomarkers; Supporting cell types; Astrocytes and BBB induction; Pericytes; Microglia

Central sensitization - (Henry Stewart Talks)

Clinical pain syndromes; What is responsible for the conversion of high threshold nociceptive pain to low threshold clinical pain?; Nociceptive pain; Neuronal plasticity; Inflammatory pain; Nociceptor sensitizors; Inflammation; Neuropathic pain

Cerebrovascular disease: realities and trends - (Henry Stewart Talks)

"The growing burden of stroke; Silent strokes, subtle thieves of mind; A comprehensive approach to prevention; A prioritized approach to stroke; Keeping up without staying up"

Challenge of Targeting Toxins to Tumors - (Henry Stewart Talks)

Generation of immunotoxins; Mode of action of different immunotoxins; Strategies to overcome the major impediments in the therapeutic application of immunotoxins to cancer patients; Anti-endoglin monoclonal antibodies and immunotoxins

Changing paradigms in anticancer drug development: inhibiting angiogenesis in colorectal cancer - (Henry Stewart Talks)

"Targeted therapy for cancer; Angiogenesis is involved throughout tumour formation, growth and metastasis; VEGF: molecular characteristics; VEGF and other signals promote the angiogenic switch in tumours; Tumour vasculature is abnormal"

Chaperone mechanisms in cellular protein folding - (Henry Stewart Talks)

The effect of protein aggregation on productive protein folding; The function of GroEL and GroES as a folding cage for proteins; Changes in energy landscape within the folding cage; Cooperation of different chaperone systems in folding pathways

Chaperone mechanisms in cellular protein folding - (Henry Stewart Talks)

The effect of protein aggregation on productive protein folding; The function of GroEL and GroES as a folding cage for proteins; Changes in energy landscape within the folding cage; Cooperation of different chaperone systems in folding pathways

Chaperones and prions - (Henry Stewart Talks)

Prion diseases; Prions as self-propagating amyloids; Yeast prions as protein-based heritable elements; Prion detection; Crucial role of the chaperone protein Hsp104 in the propagation of yeast prions

Chaperonin CCT mediated folding of actin, energetic landscapes and cell cycle control - (Henry Stewart Talks)

"CCT, an ATPase with specific protein substrates; Sequential allosteric model (2001) and allosteric cycle (2007); Actin/CCT interaction; Actin standard free energy level diagram; Functional yeast CCT; Anaphase promoting complex and WD40 propellers"

Checkpoint Blockade in Cancer Immunotherapy - (Henry Stewart Talks)

Activation of naive T-cells; CD28 and CTLA-4; Differential regulation of T-cell responses; Responding repertoire; Biological role of CTLA-4; Tumor-specific immune responses; Treg activity; CTLA-4/GVax; Immunotherapies; Conventional therapies; Ipilumumab

Chemical protein synthesis: total synthesis of proteins for biological research - (Henry Stewart Talks)

HIV-1 protease; Electronic properties of the catalytic apparatus; Defining the 'aspartyl proteases'; 'Backbone engineering' HIV-1 PR; The alpha-helix; Ubiquitin (76 aa); Conformation vs. solvation effects; Global and local structures are highly conserved

Chemical synthesis of peptides and peptide libraries - (Henry Stewart Talks)

Peptide and protein synthesis is the most robust of all synthetic chemistries; Very large combinatorial libraries with billions of different peptides are possible

Chemistry and biochemistry of molecular probes used in the detection of reactive oxygen and nitrogen species - (Henry Stewart Talks)

Reactive oxygen and nitrogen species play a critical role in physiological and pathological signaling processes

Chemistry and biochemistry of partially reduced oxygen species - (Henry Stewart Talks)

"Oxy radicals and peroxides: superoxide, hydrogen peroxide, hydroxyl, peroxynitrite; Generation by ionizing radiation and by flash photolysis; Reactivity; Thermodynamics, electrode potentials and kinetics; Fenton chemistry"

Chemistry of peptide bond formation - (Henry Stewart Talks)

Fundamental processes during protein synthesis; Peptidyl transfer catalysis by RNA-rich active site; Ribosome structure solution provided new insights; Peptide bond formation and peptide release; Active site of the ribosome

Chloroplast Development: Biogenesis of the Thylakoid Membrane - (Henry Stewart Talks)

Biology of chloroplast development including biogenesis of the thylakoid membrane system; Binding of chlorophylls to proteins determined by Lewis acid strength of the Mg;

Chloroplast Genetic Engineering - (Henry Stewart Talks)

"Advantages, concepts and methodology; Maternal inheritance and cytoplasmic male sterility; Agronomic traits to confer insect, herbicide, disease resistance, drought and salt tolerance and phytoremediation; Transformed crop species"

Chloroplast Genome and Chloroplast Gene Expression - (Henry Stewart Talks)

Early evidence for a chloroplast genome; Organization of the chloroplast genome in plants and algae; Gene content; Transcription; Roles of bacterial and phage-type RNA polymerases; Post-transcriptional modification

Chloroplast Proteome - (Henry Stewart Talks)

What is proteomics and what does it measure?; Protein identification by mass spectrometry; The problem of complex mixtures and protein identification; Quantitative proteomics and stable isotope labeling

Choosing between family-based and population-based association designs - (Henry Stewart Talks)

Population-based association analysis; Population stratification; Genomic control; Structure analysis; Principal component analysis; Family-based association analysis; Parent-of-origin effect; Genome-wide association analysis