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Dark side of amyloid: Pmel17, a natural amyloid in melanosome biogenesis - (Henry Stewart Talks)

Functional amyloid; Amyloid fibrils in melanosome ultrastructure and formation; Pmel17 processing to a fibrillar form; Evidence that Pmel17 fibrils are amyloid; Role of multivesicular bodies in Pmel17 amyloid formation

Darwinian Eye View of Cancer - (Henry Stewart Talks)

The prevalence of cancer: man vs. animals; The proximal causes of cancer: mutations and genotoxic exposures; Limitations of evolutionary adaptation by natural selection; Vulnerability to cancer from an evolutionary perspective

Death Receptor Signalling Pathway - (Henry Stewart Talks)

Death Receptors and ligands; Structural features; receptor signalling complexes; Regulation of death receptor signalling; Receptor oligomerization and internalization; Genetic diseases affecting death receptors

Degradation of Apoptotic Cells - (Henry Stewart Talks)

Apoptosis; DNA fragmentation during apoptosis; DNA degradation in macrophages; Activation of innate immunity by undigested DNA; Engulfment of apoptotic cells; Phosphatidylserine-dependent engulfment of apoptotic cells

Design and Conduct of Equivalence Trials - (Henry Stewart Talks)

Equivalence trial study design; Selection of an acceptable margin of equivalence/non-inferiority; Selection of the control (placebo/active/both); Confidence interval or hypothesis testing; Approach; Analysis population; Trial conduct

Design and Engineering of Zinc-Finger Domains - (Henry Stewart Talks)

Intro to zinc fingers; Structure and zinc ligation of classical zinc fingers; Structure and function of other types of zinc-finger domains; Designing zincless fingers (beta-beta-alpha folds); Engineering zinc ligation sites into other protein domains

Design Issues Relevant for Pharmacogenetics Studies - (Henry Stewart Talks)

"Definition of pharmacogenetics (PGx), pharmacokinetics and pharmacodynamics; Modulation of PGx phenotypes; Genetic factors play a role in determining the variability of PGx phenotypes; Study design; Genetic epidemiology; Familial aggregation studies"

Design of genome-wide association studies - (Henry Stewart Talks)

"Background to association studies; LD and the HapMap; Designing a case-control study; How many markers, how many individuals?; Estimating power; Factors that impact on power; Utilising publicly available data"

Detecting and Correcting for Population Structure in Genetic Case-Control Studies - (Henry Stewart Talks)

Population structure and false positives in case-control studies of association; Family-based solutions and TDT; Limitations of family-based solutions; Detecting population structure; Correcting for structure; Structured association and genomic control

Detecting and correcting for population structure in GWAS - (Henry Stewart Talks)

"What is population structure?; The problem of structure in association studies; Detecting unknown structure; Mixture modelling, principal components analysis; Is there a problem?; Controlling for known structure"

Detecting multiple associations in genome-wide studies - (Henry Stewart Talks)

Multiplicity; Combining evidence; False discovery rate; Q-value and local FDR; False positive report probability; Permutation testing

Deteriorating stroke - (Henry Stewart Talks)

"Causes of stroke; Pathophysiology of ischemic brain edema; Space occupying infarction; Treatment of ischemic brain edema; Causes of early deterioration after ischemic stroke; Large, space occupying edema; Edema formation after ischemic stroke"

Determinants of Susceptibility and Disease Expression (Asthma) - (Henry Stewart Talks)

"Interaction definition; Types of environmental exposures; G x E interaction: key issues and study designs; Potential methodologic issues; G x E interaction in linkage studies of asthma; ADRB2, GSTM1 and CD14 and smoking"

Determinants of Susceptibility and Disease Expression (Lung Cancer) - (Henry Stewart Talks)

Influence of host factors on individual susceptibility to tobacco smoke; Pleiotropic genes that control activation (Phase I) and detoxification (Phase II) of potential carcinogens

Development and physiology of the heart - (Henry Stewart Talks)

"Genetic basis of heart development, function and aging; Genetic model (Drosophila) for heart research; Drosophila model for congenital heart disease; Drosophila model for arrhythmias and cardiomyopathies"

Development of the peripheral nervous system in the fruitfly Drosophila - (Henry Stewart Talks)

The development of the peripheral nervous system in Drosophila serves as a model system; Isolate and characterize new genes and proteins that play a key role in neurogenesis and neural differentiation in most organisms

Developmental Origins of Obesity - (Henry Stewart Talks)

Associations between early growth and later disease; Supply of nutrients to a baby has important long term effects; Developmental plasticity; Fetal Origins Hypothesis; Childhood growth; Adiposity rebound; Effects of the physical and social environments

Developmental Plasticity, Evolution and the Origins of Disease - (Henry Stewart Talks)

Developmental plasticity; Genes and environment in development; Adaptive developmental decisions and their betrayal if conditions change; Phenotypic accommodation; Multiple pathways; Myth of single gene control; Blueprints and programs as false metaphors

Diabetes - (Henry Stewart Talks)

"Diabetes mellitus: definition, classification and its use as a model for genetic studies of complex disorders; Genetic forms of diabetes mellitus: monogenic and polygenic; Identification of diabetes genes; Monogenic forms of diabetes"

Diagnosis and treatment of dyslipidemias - (Henry Stewart Talks)

Primary dyslipidemias; Autosomal dominant and recessive hypercholesterolemia; Familial hypercholesterolemia; Familial combined hyperlipidemia; Familial hypertriglyceridemia; Familial dysbetalipoproteinemia; Pharmacotherapy; Secondary dyslipidemias

Diagnosis of Early Relapse in Ovarian Cancer Using Serum Proteomic Profiling - (Henry Stewart Talks)

Surface-enhanced laser desorption/ionization time-of-flight (SELDI-TOF) mass spectrometry data; Use of Biomarkers to identify diverse early disease detection; Ovarian cancer relapse diagnosis; SVM-MB/RFE

Diagnostic Immunohistopathology - (Henry Stewart Talks)

Techniques for identification and immunocytochemical study of proteins; Leucocyte-associated molecules; Immunhistological labeling; Immunohistological studies of human tissue; The first monoclonal anti-leucocyte antibodies

Diagnostic Methods in Autoimmunity - (Henry Stewart Talks)

IFA testing; IIF testing; Autoantibody testing; Multiplex immunoassay; Liquid arrays; Planar arrays; Systemic autoimmune disease diagnosis; SLE diagnosis; Proteomics

Dicer and R2D2 - (Henry Stewart Talks)

Double-stranded RNA (dsRNA) processing by Dicer; dsRNA-binding domain (dsRBD) protein partners (e.g. R2D2) of Dicer; Dicer-mediated RISC assembly; Sensing of thermodynamic asymmetry of small RNA duplexes by the Dicer/dsRBD partner complex

Dietary Determinants of Obesity - (Henry Stewart Talks)

Environmental factors causing weight gain and obesity; Genes interacting with dietary fat; Portion size; Eating away from home; Recommended dietary composition of a weight-reducing diet; Risk of obesity and type 2 diabetes; Role of energy density

Dimer catastrophes and plasmid resolution - (Henry Stewart Talks)

Multicopy plasmid inheritance; The causes of plasmid instability; Plasmid multimer formation and the dimer catastrophe; Plasmid dimer resolution by site-specific recombination; The Rcd checkpoint and its role in multicopy plasmid stability

Discovery of ATL and the Expansion of the Field - (Henry Stewart Talks)

Life cycle of retroviruses; Diseases derived from retroviruses; Adult T-cell leukemia and HTLV-1 retrovirus; ADF/TRX upregulation in HTLV-I T-cell and EBV B-cell transformation; Regulation of thioredoxin gene expression; TRX TG and KO mice

Discovery of Human Retroviruses and How They Cause Disease - (Henry Stewart Talks)

Human viruses that cause malignancies; The discovery of human retroviruses; Interspecies transmission of retroviruses; New human viruses/viral diseases; Adult T-cell leukemia caused by HTLV-I; HTLV-I associated diseases; Discovery of HTLV-2

Discovery Series

UCHC free programs offer information on a wide variety of timely health topics.

Diseases of Civilization: An Evolutionary Legacy - (Henry Stewart Talks)

There is a mismatch between what we were originally selected for and our modern environment; The 'diseases of civilization' result from this mismatch; Hypertension is a prototypic disease of civilization

Disorders of Overeating - (Henry Stewart Talks)

"Overeating and undereating; The hypothalamus; Satiety and hunger; Binge eating: symptoms, treatment and placebo response; Night eating syndrome (NES): provisional criteria, NES onset and stress, psychosocial factors and symptoms"

Disulfide bond formation in vivo - (Henry Stewart Talks)

"Disulfide bond formation in prokaryotes; In eukaryotes; An engineered pathway; DsbB, the source of disulfides; Disulfide isomerases"

DNA Methylation - (Henry Stewart Talks)

Roles of DNA methylation; Evolution of eukaryotic DNA methyltransferases; Mechanism of action of DNA methyltransferases; Specific loci targeting; Histone modification; Small interfering RNA

DNA Methylation - (Henry Stewart Talks)

DNA methylation as an epigenetic mark; location and patterns of methylated and nonmethylated CpG sites in the vertebrate genome; factors determining DNA methylation patterns; association of DNA methylation with stable gene silencing

DNA Methylation and Genome Defense in Neurospora crassa - (Henry Stewart Talks)

Control of DNA methylation; repeat-induced point (RIP) mutation; relationship of chromatin modifications and DNA methylation; mutants that eliminate DNA methylation; roles of histone H3 methyltransferase (DIM-5) and heterochromatin protein 1 (HP1)

DNA oxidative damage - (Henry Stewart Talks)

Formation of reactive oxygen species; Oxidative damage to DNA bases by free radicals; Techniques used for the measurement of DNA damage and repair; Biological responses to genomic DNA damage; Mechanisms of base-excision repair

DNA Replication - (Henry Stewart Talks)

Chemical composition of DNA; Chargaff's rule; DNA structure; Base pairing; Semiconservative DNA replication; Mechanism of DNA replication; Semi-discontinuous DNA replication; DNA replication is catalyzed by the cooperative action of a number of proteins

Dorsal-ventral patterning of the Drosophila embryo - (Henry Stewart Talks)

"The dorsal-ventral patterning of the early Drosophila embryo is controlled by a sequence-specific transcription factor called Dorsal, which is related to mammalian NF-?B; The Dorsal protein is distributed in a broad nuclear gradient"

Dose-Finding Trials in Oncology - (Henry Stewart Talks)

Maximum tolerable dose; Standard or 3+3 design; A+B designs; Phase I trials that use toxicity grades; Escalation versus fixed sample size designs for dose-finding trials; Continual reassessment method; Cumulative cohort design; Start-up rule

Drosha and miRNA Processing - (Henry Stewart Talks)

Definition of microRNA; Comparison to small interfering RNA; Mechanism of gene silencing; Factors in the microRNA pathway; RNase III proteins and their interacting proteins; MicroRNA gene structure and transcription

Drosophila as a model for drug addiction - (Henry Stewart Talks)

"Behaviors induced by ethanol and cocaine in Drosophila; Genes and pathways that regulate ethanol-induced behaviors: amnesiac, and the cAMP/PKA and insulin pathways; Genes and neurons that regulate cocaine-induced behaviors"

Drosophila genetics – the first 25 years - (Henry Stewart Talks)

"Sex linked inheritance, linkage and linear chromosome maps; Non-disjunction; Genic balance theory of sex determination; Chromosome aberrations; Mutational studies of the gene; X-ray induction of gene and chromosome mutations"

Drosophila stem cells - (Henry Stewart Talks)

Lineage tracing; Stem cell niches; Germline stem cell niche in ovary; Germline stem cell niche in testis; Dedifferentiation; Stem cell signaling back to the niche; Intestinal stem cells; Stem cell chromatin

Drosophila’s contribution to the genetics of learning and memory - (Henry Stewart Talks)

"Drosophila mutants defective in Pavlovian learning and memory; Training protocols and long-term memory formation; Pavlov's dogs; Biochemical signaling pathways, gene transcription and local control of protein translation"

Drug metabolism and liver disease - (Henry Stewart Talks)

Liver disease and drug clearance; Mechanistic explanations; Intact hepatocyte hypothesis; Sick cell theory; Sequential progressive model of liver disease; Viral liver disease; Alcoholic liver disease; Hepatocellular carcinoma; Liver transplantation

Drug-DNA interactions of the mitomycins - (Henry Stewart Talks)

"The mitomycins: structures, properties, early research of the molecular basis of biological activity; Reductive activation; Chemistry of the interactions with DNA: DNA adducts, cross-linking of DNA"

Drug-Induced Lupus - (Henry Stewart Talks)

The occurrence of drug and environment-related lupus and lupus-like syndromes; The medications that have been reported in association with autoimmune symptoms and syndromes; The major associations and cause(s) of these commonly noted clinical syndromes

Dynamic Human Anatomy 2.0 Dynamic Human Anatomy 2.0

Supplement to Lippincott Williams & Wilkins’s print anatomy products. Version 2.0 includes 2,600 illustrations from Grant’s Atlas of Anatomy, Eleventh Edition, Clinically Oriented Anatomy, Fourth Edition, Dean/Herbener’s Cross-Sectional Human Anatomy, and Langman’s Medical Embryology, Ninth Edition—plus 76 video clips from Acland’s DVD Atlas of Human Anatomy and six embryology animations from Simbryo, Version 1.0. Also included are 300 USMLE-style review questions in gross anatomy, embryology, and neuroanatomy. Use Internet Explorer as your Broswer.