E-Media

Browse Database Titles

ALL   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z   Others

Symbols:
- UCHC Access (Proxy Needed For Off-Campus Access)
- Free Access

E2F Family and Transcriptional Control of Cell Cycle - (Henry Stewart Talks)

Complex and diverse roles of E2F family members; Interaction with tumour repressor proteins; Interaction with chromatin modifying enzymes; Study using microarray technology and chromatin immunoprecipitation

Early detection of lung cancer - (Henry Stewart Talks)

Lung cancer is the most common cause of cancer death world-wide; Detecting and treating the disease early is the most promising approach to improve the outcome of patients with lung cancer; Strengths and limitations of current early detection technologies

Early Nutrition, Development and Health: Evolutionary Perspectives on the Metabolic Syndrome - (Henry Stewart Talks)

The Developmental Origins of Health and Disease; The thrifty genotype hypothesis; Metabolic scaling in mammals; Energy partitioning in humans; The developmental bottleneck of weaning; Baby fat as a brain buffer

Ecogenetics, Evolutionary Biology and Human Disease - (Henry Stewart Talks)

"Ecogenetics of nutrition and cultural sensitivity; Is lactose intolerance/lactase persistence a disease or an evolutionary normal variant?; Assessment, management and communication of health risks and genetic susceptibility to environmental chemicals"

Editor's Foreword - (Henry Stewart Talks)

"Genes and gene products; Role of CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6 and CYP2E1 in drug metabolism; Regulation of gene expression; Effect of genetic variation; Clinically relevant polymorphisms"

Effect of physiological factors and disease on drug metabolism - (Henry Stewart Talks)

Effect of physiological and pathophysiological conditions on drug metabolizing enzymes (DMEs); Role of growth hormones and transcription factors in sex-dependent expression; Drug clearance and age; Developmental regulation

EGFR inhibitors in NSCLC and the role of biomarkers for selection of patients - (Henry Stewart Talks)

USAEGFR TKIs in 2nd /3rd line therapy; Phase II activity of EGFR TKIs in unselected NSCLC; BR.21 study design and overall survival; Forest plot of survival by subsets; Is there a survival advantage for male smokers with squamous-cell carcinoma?

Elongation of Protein Synthesis: Structural Basis of the Peptide Bond - (Henry Stewart Talks)

The ribosome; Chemistry of peptide bond formation; Structure of the peptidyl transferase center of the ribosome; Structures of the catalytic subunit with reaction substrates and transition state analogs

Elongation of Protein Synthesis: Structural Basis of the Process of Decoding - (Henry Stewart Talks)

Fidelity in biological processes; Elongation step of protein synthesis; Ribosome structures; Errors in protein synthesis; The decoding problem; Kinetic proof-reading; Kinetic model of tRNA selection; Role of induced fit in tRNA selection

Elongation of Protein Synthesis: Structural Basis of the Process of Decoding - (Henry Stewart Talks)

Fidelity in biological processes; Elongation step of protein synthesis; Ribosome structures; Errors in protein synthesis; The decoding problem; Kinetic proof-reading; Kinetic model of tRNA selection; Role of induced fit in tRNA selection

Emerging Respiratory Viruses - (Henry Stewart Talks)

Respiratory viruses; Respiratory disease; Virus discovery; Koch's postulates; Human metapneumovirus; Human coronavirus NL63; Human coronavirus HKU; Human bocavirus

Endocrinology of Human Life History Transitions - (Henry Stewart Talks)

"The energy allocation model of life history evolution; Quantitative variation in energy allocation to reproduction; Endocrine control of qualitative, state transitions in human life history"

Endocrinology of parturition - (Henry Stewart Talks)

"Parturition; Molecular mechanisms of labor, both at term and preterm; Preterm labor; Risk factors for preterm birth; Genetics of preterm birth; Prediction and prevention of preterm birth; Treatment of preterm labor; Post-term pregnancy"

Endoplasmic Reticulum as a Calcium Gateway in Programmed Cell Death - (Henry Stewart Talks)

"Calcium signals: cardiac contraction; Intracellular calcium signals; The calcium language of cells; Cellular sources of calcium; "Calciosomes": the ER and mitochondria; Calcium probes; ER and mitochondria dynamics; ER calcium signals"

Endoplasmic Reticulum as a Most Efficient Antibody Factory - (Henry Stewart Talks)

"Studies on the synthesis, assembly and secretion of antibodies during B cell development reveal fundamental properties of the endoplasmic reticulum as a protein factory; How do cells regulate the formation, isomerisation and reduction of disulfide bonds?"

Endoplasmic Reticulum in Plants - (Henry Stewart Talks)

The secretory pathway in plants; The endoplasmic reticulum is the entry point into the secretory pathway; Protein entry in the ER; Protein synthesis on the rough endoplasmic reticulum; Protein folding; Protein export from the ER

Endoplasmic Reticulum, Protein Synthesis and Translocation Machinery - (Henry Stewart Talks)

Protein sorting in the eukaryotic cell; The discovery of the secretory pathway; Overview discussion of the structure/function of the endoplasmic reticulum; Experimental protocols and landmark experiments leading to the discovery of protein translocation

Endoplasmic Reticulum: Protein Folding and Control of Calcium Homeostasis - (Henry Stewart Talks)

Quality control; Chaperone and folding enzyme system in the endoplasmic reticulum involved in prevention of deployment of misfolded proteins; Impaired protein folding is responsible for many pathologies in humans

Endoplasmic Reticulum: The Unfolded Protein Response - (Henry Stewart Talks)

"The secretory pathway; Factor VIII expression induces ER stress; Protein folding: the ultimate and most error prone step in gene expression; The "unfolded protein response" (UPR) ensures fidelity of protein folding; UPR signaling response"

Endothelial Cell Apoptosis Regulates Normal and Tumor Tissue Damage During Radiotherapy - (Henry Stewart Talks)

Endothelial apoptosis; Role in tumor response to radiation therapy; Tissue damage results from depletion of stem cells and cells with clonogenic capacity; Radiation targets the DNA leading to reproductive (mitosis-associated) or apoptotic cell death

Endothelium and Autoimmunity - (Henry Stewart Talks)

Physiological functions of the endothelium; Endothelium as a target and player of immune responses; Endothelium in autoimmune vasculitis and vasculopathies; Anti-endothelial cell antibodies; Anti-phospholipid syndrome

Energy expenditure in the lean and obese - (Henry Stewart Talks)

History of bioenergetics; Development of the doubly labeled water method; Comparison of total energy expenditure in lean and obese; Components of energy expenditure that explain higher expenditure in the obese

Environmental Effects on Human Reproduction - (Henry Stewart Talks)

Environmental effects on human reproduction; Measuring reproductive ability; Hormonal variation and ovarian function in different populations; Effect of nutrition on reproductive function; Effect of energetics on reproductive function

Environmental Scleroderma: The Evidence for Putative Triggers - (Henry Stewart Talks)

"Lack of well-designed and conducted case-control studies that investigate the association of various occupational or environmental exposures with the subsequent development of systemic sclerosis (SSc, scleroderma)"

Epidemic of Obesity and Morbid Obesity and the Role of Bariatric Surgery - (Henry Stewart Talks)

Evolution of bariatric surgery procedures; Jejunoileal bypass; Modern malabsorptive procedures; Biliopancreatic diversion of Scopinaro; Modification of the biliopancreatic diversion to a duodenal switch; Gastric bypass; Fobi procedure

Epidemiologic and Functional Basis of Genetic Susceptibility in Granulomatous Environmental Lung Disorders: Berylliosis and Sarcoidosis - (Henry Stewart Talks)

Role of genetics x exposure in environmental lung disease; Granulomatous disorders and immunologic mechanistic basis: berylliosis and sarcoidosis; Immunogenetics that may apply generally to granulomatous disorders; Berylliosis

Epidemiology of Obesity - (Henry Stewart Talks)

"Assessment of the national prevalence of obesity; Availability of good, updated data; Problems with the data; Important determinants of obesity in Europe: age, sex and social class (education/income); Obesity prevalence in adults, adolescents and children"

Epidermal Growth Factor Receptor Family: Roles in Development and Cancer - (Henry Stewart Talks)

ERBB receptor/ligand network; Activation and intracellular signaling; Developmental roles for ERBB2 containing heterodimers; ERBB receptor structure; Molecular alterations of ERBB receptors in cancer; Targeting ERBB receptors in cancer

Epigenetic Control by Histone Methylation - (Henry Stewart Talks)

The diversity of covalent histone tail modifications for imparting epigenetic information; observations of robust histone modifications at silent chromatin regions

Epigenetic Information in Gene Expression and Cancer - (Henry Stewart Talks)

Types and functions of histone modifications; Histone code hypothesis; Epigenetics and transcription regulation; Relevance for human disease

Epigenetic Regulation of Phenotype - (Henry Stewart Talks)

"When does epigenetic reprogramming during the transfer of DNA between parents and their offspring occur, in the gametes or in early development?; inheritance of epigenetic marks"

Epigenetically Mediated Gene Silencing: Tumorigenesis - (Henry Stewart Talks)

Introduction to epigenetic changes in cancer; defining the process of promoter DNA hypermethylation as a constituent of a broad range of chromatin abnormalities in cancer; defining the genes aberrantly silenced in cancer

Epigenetics: A Historical Overview - (Henry Stewart Talks)

Introduction to epigenetics; the leading pioneers in the field of epigenetics; the basic features of development; switching and heritability of gene activities; DNA methylation; epimutations; differences between genetics and epigenetics

Esterases - (Henry Stewart Talks)

Paraoxonase (PON1); Hydrolytic reactions; Enzyme properties; Polymorphisms; Use of mouse models; PON1 levels in human populations; PON1 status as a risk factor in carotid artery disease; Designing epidemiological studies

Ethical Issues in Human Population Genetics - (Henry Stewart Talks)

The ethical issues in human genetics; ELSI issues; DNA in establishing identity; DNA in unveiling the past; DNA predicts the future; Manipulation of DNA; Ownership and control of DNA; Deeper cultural changes; Population genetics; DNA in group history

Ethical Issues in Molecular Epidemiology and Studies of Gene-Environment Interactions - (Henry Stewart Talks)

"Experiment in science policy: ethical, legal and social implications (ELSI) program; Environmental response genes; Applying genetic techniques in risk assessment: toxicogenomics; Ethical issues in the application of genomic technologies in public health"

Eukaryotic-Like Enhancer Dependent Transcription in Bacteria - (Henry Stewart Talks)

Understanding the origins of nucleotide driven conformational change; Molecular motors powered by ATP; ATPases belonging to the AAA protein family; PspF from E.coli; Phage shock genes; ATP transition state analogue ADPAlF

Evolution and Medicine: From the Perspective of an Evolutionary Biologist - (Henry Stewart Talks)

How we are mismatched to modernity; Birth control and cancer risk; Impact of early-life events on late-life obesity and diabetes; Hygiene and autoimmune disease; Evolutionary conflicts that produce reproductive problems

Evolution of Human Mitochondrial DNA Lineages - (Henry Stewart Talks)

Origins of mitochondria; Maternal pedigrees; Selective constraints; mtDNA population structure; Human origins models; Continental variation of mtDNA lineages; Distribution of synonymous and non-synonymous mutations

Evolution of Mammalian Epigenetic Control Systems - (Henry Stewart Talks)

"How, when and why did epigenetic silencing evolve in mammals?; examination of two mammal-specific systems, genomic imprinting and X-chromosome inactivation, from an evolutionary standpoint"

Evolution of morphological novelty - (Henry Stewart Talks)

Role of homeotic (Hox) genes in morphological evolution; Arthropod evolution; Crustacean appendages; The role of gene regulation in evolution

Evolution of plasmids and their role in bacterial diversity and adaptability - (Henry Stewart Talks)

Plasmids and gene exchange; Pseudomonas plasmids illustrate diversity through modular structures; Plasmid backbones and their building blocks; IncP-1 plasmids as an example of sophisticated circuitry to extend host range and minimize burden on host

Evolution of Virulence: Malaria, a Case Study - (Henry Stewart Talks)

Why are infectious agents virulent?; Evolutionary and mechanistic explanations; Natural selection on malaria virulence; Why are malaria parasites so virulent?; Why not more virulent?; Possible selective effects of public health interventions

Evolution: how Genes and their Variation got here - (Henry Stewart Talks)

Evolution by phenotype; Basic factors of evolutionary change; Mutation; Genetic drift; Natural selection; Gene flow; Current human variation; Human global Y chromosome haplotype distribution; Human global mtDNA haplotype distribution

Evolutionary and Developmental Variation in Muscle Mitochondrial Content - (Henry Stewart Talks)

Genetic origins of muscle fiber types; Allometric scaling of aerobic metabolism; Role of myonuclear domain in the muscle metabolic phenotype; Post-transcriptional regulation of mitochondrial genes; Coordination of metabolic genes during myogenesis

Evolutionary Arms Races - (Henry Stewart Talks)

Arms races and evolutionary arms races; What are they and how are they defined; Features of arms races; Who wins?: the Red Queen and the life-dinner principle; Common arms races in nature; Predators and prey

Evolutionary Behavioural Genetics and Mental Disorders - (Henry Stewart Talks)

"Ways of assessing heritability in humans: twin and adoption designs; The evolutionary paradox of common, heritable mental disorders; Possible resolutions to the paradox: balancing selection, neutral mutation and polygenic mutation-selection balance"

Evolutionary Biology of Depression - (Henry Stewart Talks)

Depression has a genetic component and can be triggered by stress; It is a common mental illness; Why has it not been selected out?; Sadness is adaptive but depression is probably not

Evolutionary Considerations and the Endothelium - (Henry Stewart Talks)

The endothelial organ; Proximate mechanisms of endothelial cell heterogeneity; Evolutionary mechanisms of endothelial cell heterogeneity; Hagfish as a model for early endothelium

Evolutionary Ecology of Immunity - (Henry Stewart Talks)

Why immune defense matters; Asking for evolutionary reasons and constraints; Using immune defenses is very costly for the individual; The nature of the costs; Differences among the sexes; Specific defenses and their impact; What would be the best defense