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Fabry Disease: Galactosidase A Deficiency & Enzyme Replacement Therapy - (Henry Stewart Talks)

Diagnosis of Fabry disease; Metabolic defect: GL-3 accumulation; Multi-systemic manifestations; Case examples; Kidney pathology in Fabry disease; Enzyme therapy; Dialysis and transplantation; Analogy to diabetic nephropathy

Factor independent initiation of protein synthesis by IRES RNAs - (Henry Stewart Talks)

Translation initiation in eukaryotes: two pathways; IRES-driven translation; Types of IRESes; IRES manipulation of ribosomes; Folding and structure of the IGR IRESes; IRES interactions with the ribosome and molecular mimicry

Factor IX - (Henry Stewart Talks)

Factor IX; Blood coagulation; Thrombus formation; Factor IX gene; Vitamin Kdependent proteins and gamma-carboxyglutamic acid; Factor IX: biochemistry and structure; Hemophilia B

Factor VIII and Haemophilia A - (Henry Stewart Talks)

Normal blood coagulation; What is haemophilia A?; Different types of factor VIII gene mutations; Loss of protein or loss of function; Structural interpretation of protein dysfunction; Other rare causes of FVIII deficiency

Familial hyperchlolesterolaemia: a monogenic cause of early CHD - (Henry Stewart Talks)

"Clinical diagnostic criteria; Prevalence in UK; Effects of statins on cholesterol and CHD risk lowering; The 3 genes where mutations cause FH (LDLR, APOB, PCSK9); Clinical Genetics Diagnostic service for FH and examples in families"

Family-based association tests: FBAT testing strategies for large-scale association studies - (Henry Stewart Talks)

Genome-wide association studies; Using same data set for screening and testing; Conditional mean model; FBAT-statistic; Genetic model under the alternative hypothesis; Concept of the conditional mean model; Screening technique for multiple markers

Family-based association tests: FBATs for various data types - (Henry Stewart Talks)

Childhood asthma management program (CAMP); Multivariate tests; FBAT-GEE; FBATs for time-to-onset data; Time-to-onset data for complex diseases; FBAT logrank and Wilcoxon; Quantitative trait analysis; Quantitative traits for complex diseases

Family-based association tests: introduction - (Henry Stewart Talks)

Definition: genetic association; Examples; Linkage disequilibrium; Case-control analysis; Samples from mixed populations; Population admixture; Dichotomous trait; The transmission disequilibrium test (TDT); An alternative formula for the TDT: FBATs

Fast Folding Dynamics of Small Proteins: Placing Limits on Diffusional Limits - (Henry Stewart Talks)

Basic time scales and diffusional limits in protein folding; Applying reaction rate theories to folding; Kramers behavior and friction; Internal friction of polymer chains; Evidence for (or against) internal friction in protein folding

Fever and Related Defenses - (Henry Stewart Talks)

Evolutionary history of fever; Role of fever in disease; Role of related host defenses in disease; Concept of Darwinian Medicine

Fibrinogen and Factor XIII - (Henry Stewart Talks)

Fibrinogen and factor XIII; Structure; Biosynthesis; Fibrin polymerization; Crosslinking; Clot mechanical properties; Interactions with other proteins; Fibrinolysis; Platelet aggregation; Dysfibrinogenemias and variants; Evolution

Fibrinolysis - (Henry Stewart Talks)

"Biochemistry and physiology of fibrinolysis; The balance of fibrinolysis in blood, activators and inhibitors; Assays of fibrinolysis, clot lysis, model thrombi under flow, in situ zymography and euglobulin lysis; Genetic deficiency syndromes"

Filoviruses - (Henry Stewart Talks)

"Filovirus history; Filovirus genes, proteins and structure; Filovirus replication cycle; Evasion of interferon responses by filoviruses; Filovirus vaccines"

Fine Scale Mapping - (Henry Stewart Talks)

Linkage vs. association; The need for fine mapping; The genealogy underlying a sample of case chromosomes; Disease-marker association; Star genealogies and variance adjustment; Coalescent-based approaches; Software: DMLE+ and COLDMAP; Example: CF dataset

Folding and Design of Helical Repeat Proteins - (Henry Stewart Talks)

"Repeat proteins versus globular proteins; Consensus design, the role of conserved hydrophobic residues; Co-variation can modulate stability, but is not essential to specify a stable fold; Structure and stability of the designed CTPR proteins"

Forebrain mechanisms of pain modulation - (Henry Stewart Talks)

Involvement of the forebrain in pain perception; Descending pain control pathways from cortex; Attentional modulation of pain; Emotional modulation of pain; Empathy and pain; Placebo analgesia

Formulating input uncertainty - (Henry Stewart Talks)

How to express uncertainty about model inputs; The analysis of the vaccine model exemplifies the basic approaches; Accounting for data gaps; Recognizing correlation between uncertain inputs; Evaluating uncertainty in utilities

From germ cell specification to gonad formation - (Henry Stewart Talks)

Germ cells: the ultimate stem cell; Germ plasm specifies germ cells; The genetics of early Drosophila development: maternal effect mutations; The body pattern of the embryo is preformed during oogenesis by localization of RNA

From Viruses to Oncolytics - (Henry Stewart Talks)

"Viruses: molecular biology and reverse genetics; Tropism determinants: entry and post-entry levels; Tropism targeting: protease activation, receptor attachment, transcription/replication, spread"

Frontotemporal Dementia Syndromes - (Henry Stewart Talks)

Clinical spectrum FTD; Frontal or behavioural variant; Semantic dementia; Progressive non-fluent aphasia; Disease overlap; Genetic factors; Epidemiological facts; Neuropsychological methods and imaging diagnostics; Pathological groupings of FTD

Function of molecular chaperones in bacterial infection - (Henry Stewart Talks)

Molecular chaperones bind non-specifically to many unfolded proteins and selectively to folded-specific proteins to regulate their activities; Different chaperone systems are involved in successful infection of the host with various pathogenic bacteria

Functional pain disorders - (Henry Stewart Talks)

Visceral pain disorders; Epidemiology of IBS; Overlap of IBS with other functional pain syndromes; Is there a shared CNS abnormality in functional pain disorders?; Reported alterations in brain responses in stress-sensitive pain syndromes

Functions of the Hsp70 system - (Henry Stewart Talks)

Early steps and problems in nascent protein folding; Molecular chaperones prevent protein aggregation; Heat shock protein (molecular chaperone) classes; Hsp70: characteristics and mechanism of action; Hsp70 function and cancer (prevention of apoptosis)

Fundamentals and Principles for Engineering Proteolytic Activity - (Henry Stewart Talks)

Protein engineering goals; Applications of engineered proteins; Strategies for engineering proteins; Specific examples of redesigned proteases to understand structure/function relationships; Engineered catalysis and molecular recognition in proteases