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Gastroenteritis Viruses - (Henry Stewart Talks)

Viruses causing diarrhea; Epidemiology; Rotavirus pathogenesis; Rotavirus infection in calves; Rotavirus genes and proteins; Rotavirus replication; NSP4; Properties of rotavirus enterotoxin; Treatment and vaccines; Norovirus; Norovirus pathogenesis

Gene and Protein Microarrays: Tools for Gene Discovery and Function - (Henry Stewart Talks)

"High-throughput methods to examine global gene expression; Understanding interactions in a given cell, tissue and organism under normal and disease state conditions; Application of high throughput methods used in genomics and proteomics"

Gene profiling in breast cancer - (Henry Stewart Talks)

"DNA microarrays and PCR can provide information about the biology of breast cancer, prediction of response and prognosis; A molecular taxonomy of breast cancer has been proposed based on gene profiling"

Gene Silencing by Polycomb Complexes - (Henry Stewart Talks)

Discovery of the Polycomb group (PcG) of proteins; Role in embryogenesis; Species conservation; Latest developments in understanding molecular mechanism of gene silencing; Evidence on hierarchical recruitment

Gene therapy as a therapeutic option for lipoprotein lipase deficiency - (Henry Stewart Talks)

No treatment for genetic lipoprotein lipase (LPL) deficiency; This disorder has several specific characteristics which make it a feasible target for gene therapy approaches; Development of LPL transgene delivery; Use of adeno-associated virus

Gene-by-Environment Interaction: Study Designs and Analytical Methods - (Henry Stewart Talks)

"Study designs that evaluate the joint effects of gene-by-environment interactions, including case-control, case only, matched pairs, random samples and family studies; Distinguishing between gene-by-environment interaction and genetic heterogeneity"

Gene-by-Environment Interactions in COPD - (Henry Stewart Talks)

Chronic Obstructive Pulmonary Disease (COPD) and cigarette smoking; Gene x environment interactions in COPD; Alpha 1-antitrypsin as a rare major genetic risk for COPD; Familial aggregation of COPD within smokers

Gene-environment interaction and oxidative stress in cardiovascular disease - (Henry Stewart Talks)

Oxidative stress: a risk factor for CVD; Biochemical markers of oxidative stress; Genetic determinants of oxidative stress: examples; Examples of gene-environment interaction in determining oxidative stress and CVD

General management - (Henry Stewart Talks)

Organization of stroke care; What is a stroke unit?; Early mobilization; Monitoring of neurological status and vital physiological functions; Blood pressure management; Cardiac care; Oxygen saturation; Blood glucose management

General properties and applications of plasmids - (Henry Stewart Talks)

Properties of plasmids that facilitate isolation; Basic analyses of plasmids; Restriction enzymes and their use as analytical tools; The important role of plasmids in recombinant DNA technology and genome analyses

Generation and propagation of infectious prions by cyclic amplification of protein misfolding - (Henry Stewart Talks)

Prions as infectious proteins and the mechanism of replication; The rationale and proof of concept for the PMCA technology; Multiple applications of PMCA; Generation of infectious prions by PMCA; Studies of prion strains and species barrier

Generation of Diversity in Antibody Genes - (Henry Stewart Talks)

Historical perspective on antibodies and immunity; Nature and structure of antibodies and immunoglobulin fold; Theories of antibody formation; Clonal selection theory; Mechanisms contributing to antibody diversity; Organization of immunoglobulin loci

Generation of reactive oxygen species by mitochondria - (Henry Stewart Talks)

Oxygen chemistry; Reactive oxygen species chemistry and in disease; Antioxidants defenses; Mitochondria structure and topology; Mitochondria bioenergetics; Sites and mechanisms; Superoxide dismutase; Mitochondrial GSH

Genes and Cells Therapy - (Henry Stewart Talks)

Use of human autologous stem cells in patients that suffer from liver diseases; Stem cells specialize in repairing damaged tissues and regenerating damaged organs; Omnicyte is a particular type of CD34+ hematopoietic stem cell

Genes in Common Disease - (Henry Stewart Talks)

"Nature vs. nurture; Types of genetic disorders; Continuum of genetic influence; Breast cancer: epidemiology, clinical manifestation and genetic factors; Genetic testing and future research in breast cancer; Colorectal cancer"

Genetic analysis of meiosis in Drosophila melanogaster females - (Henry Stewart Talks)

Identification of genetic material; The central dogma of meiosis; Nondisjunction frequencies for the Drosophila genome; A revised view of meiosis; Chromosome segregation; A mutational approach to understanding the meiotic process

Genetic and Environmental Triggers of Autoimmune Thyroid Diseases - (Henry Stewart Talks)

Autoimmune thyroid diseases (AITD): Graves' diseases (GD) and Hashimoto's thyroiditis (HT); The pathogenesis of GD and HT involves infiltration of the thyroid by T lymphocytes

Genetic architecture of complex traits: lessons from Drosophila - (Henry Stewart Talks)

Complex traits; Identifying multiple genes and environmental risk factors; Nature of genetic variation affecting complex traits; Drosophila as a model system; P-element mutagenesis; Whole genome transcript profiles of genetically divergent strains

Genetic Association Studies, TDT and the Candidate Gene Approach - (Henry Stewart Talks)

Background of genetic studies; Structure of a gene; Simple association; Linkage disequilibrium and haplotypes; Multi-marker association; Family-based association; Practicalities of programs and power

Genetic Conflicts in Human Pregnancy - (Henry Stewart Talks)

The association of maternal provisioning of a fetus and opportunity cost; The relationship between maternal investment in fetus to the benefit to the fetus and the cost to its siblings; The maternal-fetus unit

Genetic Defects and Calcium - (Henry Stewart Talks)

General concepts of calcium signaling; Mechanisms of calcium extrusion/uptake; Mechanisms of calcium release from the ER/SR; General concepts about plasma membrane calcium channels; Genetic defects of calcium release channels

Genetic Determinants of Adverse Drug Reactions - (Henry Stewart Talks)

Type A and B Adverse Drug Reactions (ADRs); Pharmacokineticpharmacodynamic paradigm; ADME framework; Mechanisms of ADRs; Pharmacogenetics and pharmacogenomics; Polygenic traits; Environmental factors; Phenotype and endophenotype

Genetic Determinants of Antipsychotic-Induced Weight Gain - (Henry Stewart Talks)

Antipsychotic drugs: limitations and side effects; Drug-induced weight gain; Severity and consequences; Receptor mechanisms; Role of 5-HT2C receptor; Pharmacogenetics of antipsychotic weight gain: 5-HT2C promoter polymorphism

Genetic Determinants of Drug-Induced Tardive Dyskinesia: Part I - (Henry Stewart Talks)

Postulated mechanisms of schizophrenia; Dopaminergic pathways in schizophrenia; The Pharmacogenetic paradigm; Pharmacokineticpharmacodynamic-environmental interactions; Complex trait genetics; Antipsychotic adverse reactions

Genetic Determinants of Drug-Induced Tardive Dyskinesia: Part II - (Henry Stewart Talks)

Pharmacokinetics and TD: a look at the cytochrome P450 system; Oxidative stress and TD: a look at free radicals and the superoxide dismutase genes; Psychiatric pharmacogenetics as cleaner complex phenotypes

Genetic Determinants of Metabolism: Clinical Applications in Psychiatry - (Henry Stewart Talks)

Factors that determine psychiatric importance of genetic variants; Consequences which arise from genotyping; Drugs are metabolized via the polymorphic cytochrome P450 enzyme CYP2D6

Genetic Diseases in the Jewish Population - (Henry Stewart Talks)

"Jewish history and genetics; Classification of Jews; Genetic diseases found in Jews, particularly Ashkenazi Jews; Lysosomal storage diseases; Natural selection (heterozygote advantage) vs. genetic drift; Mutation frequencies"

Genetic Disorders of Carbonic Anhydrases II and IV - (Henry Stewart Talks)

Carbonic anhydrase deficiencies; History of the disease; Roles of CA II and IV in disease; Sulfonamide inhibitors for treatment of some disorders; Characterization of CA isozymes; CA IV discovery and function; Mouse knockout models of CA deficiencies

Genetic Linkage Analysis - (Henry Stewart Talks)

Likelihood formulations for genetic analysis of family data; The statistical framework for segregation and linkage analysis; Types of sampling approaches useful for linkage analysis; Modelling of linked genetic markers

Genetic polymorphism of thiopurine methyltransferase and thiopurine therapy: from molecular genetics to clinical medicine - (Henry Stewart Talks)

"Potential of pharmacogenomics to optimize cancer chemotherapeutics; The well-defined genetic polymorphism of thiopurine methyltransferase (TPMT); Its influence on thiopurine (e.g., mercaptopurine, azathioprine) therapy"

Genetic Polymorphisms Influencing Response to Lithium - (Henry Stewart Talks)

Lithium treatment in the long-term maintenance of mood disorders; The issue of evaluating lithium response; Role of genetic factors; Mechanism of action of lithium candidate genes in lithium response; Inositol polyphosphate 1- phosphatase (INNP1)

Genetic testing for CHD risk: fact or fiction? - (Henry Stewart Talks)

"Family history is a strong independent risk factor for early CHD; Criteria for useful CHD-Risk DNA tests; Analytical validity; Clinical validity; Risk estimates for genetic effects; Clinical utility; Risk score methods; CRP: origin, clearance and function"

Genetic Variation and Human Disease - (Henry Stewart Talks)

Proximal vs. ultimate causation; Causes of death in modern societies; Quantifying genetic causation; Relative risks of common diseases; Fitness; Why do genetic diseases exist?; Selection can maintain disease; Mutation-selection balance; Evolutionary lag

Genetics and biology of the [Het-s] prion of Podospora - (Henry Stewart Talks)

"Mammalian prions; Fungal prions; Yeast: [URE3], [PSI+] and [PIN+]; Filamentous fungi: [Het-s]; Fungal self non-self recognition; Heterokaryon incompatibility; Genetics of [Het-s]; Maternal inheritance; Meiotic drive"

Genetics of Autoimmune Diseases - (Henry Stewart Talks)

Autoimmune diseases; Autoimmune kaleidoscope; Clinical evidence; Familial autoimmune diseases; Physiopathology; Autoimmune diseases are heterogeneous and multifactorial; How important is the genetic predisposition on susceptibility to autoimmune diseases?

Genetics of Breast and Ovarian Cancer - (Henry Stewart Talks)

General cancer genetics; Tumor suppressor and oncogenes; Knudson's 'two hit' hypothesis; Genetic predisposition to breast and ovarian cancer; How much breast and ovarian cancer is inherited and the causes (genes responsible)

Genetics of cardiovascular disease - (Henry Stewart Talks)

Conventional CVHD risk factors; Multifactorial nature of CVD; Gene-environment interaction and how to test for it; Candidate gene approach to CVD genetics vs. genome-wide scans

Genetics of chemosensory transduction: taste and smell - (Henry Stewart Talks)

Smell; Taste; Comparative analysis of these senses in vertebrates and insects; Functional relevance of the chemical senses; Logic of taste coding; Logic of olfactory coding; Chemosensory receptors; Mechanisms of olfactory signal transduction

Genetics of French Canadians - (Henry Stewart Talks)

Founder effect; Population history and the French Canadian founder effect; The contemporary population in relation to its founders; Regional gene pools: the examples of the Saguenay and the Gaspesie regions; Regional distribution of disease mutations

Genetics of pain - (Henry Stewart Talks)

Variability in pain sensitivity and analgesia; Heritability of pain; Genetic and environmental contributions to pain; Pain genes; Monogenic pain disorders; Association studies

Genetics of Pakistani Populations in an Asian and Global Context - (Henry Stewart Talks)

"Population genetics; Pakistan and south west Asia; Human migrations; DNA markers; Alu repeats, SNPs and STRs; Y chromosome, mitochondrial DNA and HLA markers unravel genetic relationships among populations in Asia and Pakistan"

Genetics of Phase I Enzymes - (Henry Stewart Talks)

"Inter-patient variations caused by Phase I drug metabolizing enzymes; Genetic polymorphism of CYP2D6 and impact on psychopharmacotherapy; Metabolism, pharmacokinetics, pharmacodynamics and toxicity"

Genetics of Phase II Enzymes - (Henry Stewart Talks)

"Phase II metabolism; Conjugation of drugs and other xenobiotics with a range of different molecules including glucuronic acid, sulfate, amino acids, acetyl groups, methyl groups and glutathione"

Genome scale analysis of cellular processes using RNAi - (Henry Stewart Talks)

Functional analysis in Drosophila; RNAi; Genetic screens by RNAi; RNAi libraries; Cell-based assays; Screen analysis; Systematic analysis of high-throughput data; Normalization and hit identification; Challenges in quantitative image analysis

Genome scanning by composite likelihood - (Henry Stewart Talks)

The nature of complex traits and introduction to linkage and association mapping; Measures of linkage disequilibrium; Methodology for constructing linkage disequilibrium maps and their properties; Application to different human populations

Genome scans for hypertension - (Henry Stewart Talks)

Hypertension: cause of 4.5% of global disease burden; Causes of hypertension; Complex trait: multiple risk factors; Strategies for finding genes; Candidate gene analysis; Genome-wide scans; Blood pressure traits; Genes with major effects?

Genome-Wide Analyses - (Henry Stewart Talks)

Identifying genomic targets of DNA-binding factors; Experimental methods; Chromatin immunoprecipitation (ChIP) assay; Probing microarrays; ChIP-on-chip assays for comprehensive analysis; Data interpretation and follow-up studies

Genome-Wide Scans - (Henry Stewart Talks)

Genome-wide vs. candidate gene search methods; Linkage vs. association; How to cope with multiple comparisons; Ordered sequential methods; Latest meta-analysis methods for LOD score analysis

Genomic Imprinting and its Regulation - (Henry Stewart Talks)

Introduction to imprinting; classic embryological and genetic studies; identification and function of imprinted genes; imprinted domains and the organisation of imprinted clusters; epigenetic modifications and genome programming

Genomic Imprinting: History and Embryology - (Henry Stewart Talks)

Emergence of imprinting as a concept from experiments involving reciprocal nuclear transfer in the mouse zygote; construction of embryos containing only the male genome (androgenones) or the female genome (gynogenones)