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Handling of Missing Data in Clinical Trials - (Henry Stewart Talks)

The missing data problem; Missing at random (MAR); Industry experience in the handling of missing data; Last observation carried forward (LOCF); Mixed model repeated measures model (MMRM); Multiple imputation (MI); Sensitivity analysis; ICH guidelines

Haplotype Phase Inference - (Henry Stewart Talks)

The problem of haplotype phase prediction and inference of frequencies; Computational methods: parsimony and Clark's algorithm; Computational methods: maximum likelihood and the EM algorithm; Computational methods: Bayesian approaches

Haplotype-Based Mapping and Pharmacogenetics - (Henry Stewart Talks)

Pharmacogenetics: a simpler complex trait?; Mapping strategies: map-based and sequence-based; Tagging SNPs: definition and assessment; Case study: tagging in 56 drug transport and metabolism genes; tSNP efficiency

HapMap Project - (Henry Stewart Talks)

The problem in pedigree analysis; A possible solution for the resolution limitations in pedigree analysis; Theory of two loci; Linkage equilibrium and disequilibrium; Recombination events between SNPs; Genealogical interpretation

Hard Tissue Biology in Human Health and Evolution - (Henry Stewart Talks)

Dental development; Enamel structure and anti-crack propagating characteristics; Global climate change and human tooth evolution; Dental and facial health issues; Bone structure and mechanical factors with aging; Bone health issues; Bone health in space

Harnessing Tolerance Mechanisms with Monoclonal Antibodies - (Henry Stewart Talks)

Transplantation; Alemtuzumab; Routes to transplantation tolerance; Tolerization to the tissue itself; Achieving mixed chimerism; Self-tolerance; Blockade of co-receptors and co-stimulatory molecules with monoclonal antibodies

Health Disparities in Common Complex Diseases: A Role for Genetics? - (Henry Stewart Talks)

"Genetic epidemiology of common, complex and chronic diseases; Evidence of a role for a genetic basis of health disparities; Genetic studies on asthma and allergic disease and ethnicity; Geneenvironment interactions; Biogeography and the hygiene hypothesis"

Health Economics of Obesity: New Insights - (Henry Stewart Talks)

"International cost estimates; Benchmark cost estimates; Direct cost in the US by demographics; Impact on productivity; Impact of weight loss on health care costs: lifestyle, pharmacotherapy and surgical interventions"

HealthEcademy

Features several video presentations by UConn School of Medicine faculty and other Health Center experts who provide practical information on a number of health-related topics so you can become a better, more successful patient – and patient advocate.

Hepatitis C and HCV - (Henry Stewart Talks)

The spectrum of hepatitis viruses; Global distribution of HCV infection; Associated diseases; Hepatitis C pathogenesis; HCV model systems; Replication of HCV RNA; Hypothetical membrane topology of HCV proteins; HCV structural proteins; p7 protein

Heritable Disorders of Collagen - (Henry Stewart Talks)

Collagen biosynthesis; Collagen structural assemblies; Linkage of disorders to collagen mutations; Linkage of Ehlers-Danlos syndromes (EDS) to either collagen mutations or enzyme deficiencies

Heterogeneity: Problems and Solutions - (Henry Stewart Talks)

"Heterogeneity: definitions and effects; Phenotypic, genotypic, population and penetrance/expression heterogeneity; Population stratification: case study; Detecting heterogeneity: Tree models; Classification vs. regression TREEs"

HGF receptor, a Targettable Regulator of Invasive Growth - (Henry Stewart Talks)

"Trigger of invasive growth by specific signals; Invasive growth receptors; The "receptosome"; Dynamics of invasive growth signalling; MET transcriptome; HGF regulated genes; Hypoxia regulates MET transcription; The effector machinery of invasive growth"

High resolution structure of ribosomal subunits RNA/RNA and protein/RNA interactions - (Henry Stewart Talks)

X-ray crystallography; Protein synthesis; High resolution structure of ribosomal subunits; RNA motifs and interactions; RNA protein interactions; Metal ions stabilizing RNA structure

Histone Dynamics, Heritability and Variants - (Henry Stewart Talks)

DNA is organized into chromatin which promotes compaction and brings about additional information; the histone code hypothesis; chromatin dynamics and heritability; factors involved in chromatin dynamics

Histone Dynamics, Heritability and Variants - (Henry Stewart Talks)

DNA is organized into chromatin which promotes compaction and brings about additional information; the histone code hypothesis; chromatin dynamics and heritability; factors involved in chromatin dynamics

Histone Modification and Transcriptional Repression - (Henry Stewart Talks)

Mechanisms of transcriptional repression; Corepressor proteins; Histone modifications involved in repression; Cancer

Histone Modifications and Prospects for an Epigenetic Code - (Henry Stewart Talks)

Enzyme-catalyzed modification of the N-terminal tail domains of core histones provides an array of marks across the nucleosome surface and a source of epigenetic information

Historical and Ethical Issues in Trial Design - (Henry Stewart Talks)

Historical instances highlights of experimentation on human subjects; Creation of modern therapeutics and pharmacology; Development of biostatistical techniques for drawing inferences from aggregate data; Medical Research Council and the streptomycin tria

Historical and Geographical Genetic Variation: Europe - (Henry Stewart Talks)

Origin of modern Europeans; Genetic tools; Neanderthal vs. modern humans; Complete mitochondrial DNA sequences: new data on the early events after the Out of Africa exit; Paleolithic vs. Neolithic origin of the European gene pool

Historical Perspective on Ideas on X-Chromosome Inactivation - (Henry Stewart Talks)

The phenomenon of X-chromosome inactivation in female mammals; X-chromosome inactivation as a dosage compensation mechanism for equalising the dosage of X-linked gene products in XY males and XX females in somatic cells

History and Geography of Human Genetic Diversity I - (Henry Stewart Talks)

"Four major factors of evolution: mutation, natural selection, drift, migration; Role of demography in the quantitative study of evolution; Drift: the Parma Valley study; Equilibrium of migration and drift; Founders' effect"

History and Geography of Human Genetic Diversity II - (Henry Stewart Talks)

Genetic markers inherited from a single parent; Mutational history of the Y chromosome (NRY); Genealogies of Y chromosome and mitochondria; Of Adam and Eve; Primates and Homo sapiens; Neanderthal and the spread of modern humans from East Africa

History and Geography of Human Genetic Diversity III - (Henry Stewart Talks)

"The human genome diversity project (HGDP); Method structure; Limitations of HGDP-CEPH; Are the clusters established by structure "good" races?; Correlation between genetic and geographic distance"

History of the molecular chaperone concept: roles in assembly processes - (Henry Stewart Talks)

Definition of protein self-assembly and aggregation; First use of the term 'molecular chaperone'; Nucleoplasmin; Chloroplast rubisco aggregation; The chaperonins; The general chaperone concept; Definition of 'molecular chaperone'; The chaperone function

HIV Preintegration Complexes - (Henry Stewart Talks)

Role of cell cycle progression in retrovirus replication; Resting T-cells and HIV; Uncoating and PIC nuclear import; Preintegration complex (PIC); Intracellular transport of PIC; HIV-1 Vpr vs. HIV-2 Vpx; HIV-1 Vpr interaction factors; HIV-2

HIV Prevention and Public Health Issues: a Global Perspective - (Henry Stewart Talks)

HIV transmission and epidemic; HIV prevention science; HIV testing; Models at population and individual level; Examples of prevention successes; HIV and sexually transmitted diseases; Antiretroviral therapy as a prevention modality

HIV Preventive Vaccines - (Henry Stewart Talks)

HIV distribution; HIV in Africa; HIV particle; T-cell responses; CD4 T-cells susceptible to HIV infection; CD8 T-cells control HIV infection; Acute HIV infection; HIV escape mutations when CTL response focused on dominant epitope; Immune control of HIV

HIV/AIDS Epidemiology, Transmission and Risk Factors - (Henry Stewart Talks)

HIV: greatest pandemic; Global view of HIV infection; Global distribution of subtypes; HIV infection; Target cells for infection; Routes of transmission of HIV and risk; Viral mucosal interface; Determinants of HIV infection; Viral factors in transmission

HIV/AIDS in the Developing World: What Can We Do? - (Henry Stewart Talks)

"Global HIV epidemiology; Scope of the problem; The context of development: poverty, displacement, other health concerns; Necessity of responding; What is being done?; Impact of current efforts; Unique role for health professionals and scientists"

HIV: Peculiarities of its Genome - (Henry Stewart Talks)

Molecular organization of HIV; HIV-1 mRNAs; Env and HIV-1 entry; Tat and Rev are essential RNA binding HIV-1 proteins; HIV-1 promoter; HIV-1 mRNA expression; Retroviruses and Env-containing LTR-retroelements

Homeotic genes of the bithorax complex in Drosophila - (Henry Stewart Talks)

"Flies are made of segments; Homeotic mutations transform one body segment into another one; Ed. Lewis the father of "Developmental Genetics"; Crash course in bithorax genetics; The model of Ed Lewis; “Gain-of-function” versus “loss-of-function” mutations"

Hormonal influence on bone remodeling and its implications for the pathophysiology of osteoporosis - (Henry Stewart Talks)

Birth and fate of osteoblasts and osteoclasts; Mechanical loading; Role of osteocytes in mineralization; Sclerostin; The cell number concept; Osteoporosis; Anti-osteoporotic effects of sex steroids and their cellular mechanisms

Hormones: the molecules that serve as chemical messengers - (Henry Stewart Talks)

"History of the study of hormones; Fundamental concepts of the structure, synthesis and secretion of hormones with emphasis on vertebrate systems; Molecular diseases of endocrine systems"

How aminoacyl-tRNA synthetases translate the genetic code - (Henry Stewart Talks)

Fidelity of protein synthesis; Architecture of aminoacyl-tRNA synthetase; ATP and amino acid recognition by the two classes of synthetases; The activation reaction; Cognate tRNA recognition by synthetases; The aminoacylation reaction

How HIV Causes Disease - (Henry Stewart Talks)

"HIV infection: the target of HIV infection, the level of virus in the blood, infection kinetics; Viral factors influencing HIV disease progression: assembly into new virions within 1-2 days, formation of mutations in viral proteins; Host factors influencing HIV disease progression"

How trypanosomes cope with oxidative stress - (Henry Stewart Talks)

Trypanosomes: causative agents of neglected diseases; Uniqueness of redox metabolism in trypanosomes; Detoxification of hydroperoxides and peroxynitrite; Biosynthesis and function of trypanothione; Validation of targets for trypanocidal drugs

Hsp104: a specialized chaperone for protein disaggregation - (Henry Stewart Talks)

Heat shock; Molecular chaperones and thermotolerance; Protein aggregation and refolding; Prions in mammals and yeast; Molecular chaperones and protein aggregation associated with human disease

Hsp31: a general stress protein of Escherichia coli - (Henry Stewart Talks)

Stress proteins and molecular chaperones in E. coli; Hsp31: an ATP-regulated molecular chaperone; Hsp31 structure; Hsp31 mechanism of action; Role in the management of severe thermal stress; Regulation and mechanism of thermal induction

Hsp90: a chaperone for protein kinases and hormone receptors - (Henry Stewart Talks)

Chaperoning steroid receptors; the Hsp90 chaperoning machine; Hsp90 structure and function; Chaperoning protein kinases and other Hsp90 clients

Human Antibodies Produced in Rodents - (Henry Stewart Talks)

Immune development; Human Ig loci; Transgenesis; Human antibody repertoires; Monoclonal human antibodies; Silencing mouse antibody production; B-cell receptor structure; Flow cytometry; Therapeutic Ig

Human Fertilisation and Embryology Authority - (Henry Stewart Talks)

Background to UK regulation of embryo research and hESC research; The Human Fertilisation & Embryology Act (1990); The licensing process; Strengthening science through regulation; Public attitudes towards embryo research and regulation

Human Genetic Variation and Therapeutic Development - (Henry Stewart Talks)

"Common variation within the human genome; The drug discovery pipeline; The contribution of genetic variation to target identification, validation and clinical development; Defining drug targets; Genotype phenotype correlation; Druggable genome"

Human Genetic Variation of Africa - (Henry Stewart Talks)

Neutral genetic variation and African prehistory; Non-neutral genetic variation of Africa and natural selection; Social and medical implications of genetic variation in Africa; Resources

Human Genome Variation - (Henry Stewart Talks)

DNA polymorphisms in the human genome; Identification of a large number of common Single Nucleotide Polymorphisms (SNPs); The relationship of these common SNPs in linkage disequilibrium bins

Human Genomes - (Henry Stewart Talks)

The nature of genetic polymorphism; Single nucleotide polymorphisms; Differences between genomic regions; Differences between populations; Inferences about human history from genetic variation; Detecting natural selection

Human Microsatellite and Minisatellite DNA Polymorphisms - (Henry Stewart Talks)

Microsatellites: nomenclature and definitions; Discovery; Typing methodology; Abundance and types; Applications; Mutation; Biological functions; Evolution; Minisatellites

Human neurodegenerative disease: insights from Drosophila genetics - (Henry Stewart Talks)

The fly as a model for human disease; Modelling human polyglutamine disease; Molecular chaperones as modifiers of polyglutamine disease using the fly; Importance and impact of disease protein function for effects of the toxic mutant protein

Human Population Genetics: Lifespan - (Henry Stewart Talks)

Human lifespan as a heritable trait; Lifespan phenotypes; Genetic epidemiology of human lifespan; The genetic architecture of human longevity; Genetic study designs in longevity research

Human Population Structure - (Henry Stewart Talks)

Geographic distribution of genetic variants; Private alleles; Pairwise differences between individuals; Partition of genetic variation; Population structure and inference of ancestry; Decline of heterozygosity with distance from Africa