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Idiopathic Thrombocytopenic Purpura - (Henry Stewart Talks)

Idiopathic thrombotic thrombocytopenic purpura; Diagnosis; Treatment; Prognosis; Recent discoveries in pathophysiology; ADAMTS13 metalloprotease; Clinical studies in familial and autoimmune TTP; Frontiers of clinical research

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Images.MD has over 50,000 medical images from more than 90 collections and 2,000 contributors.

Imatinib as a Paradigm of Targeted Cancer Therapies - (Henry Stewart Talks)

"Clinical description of chronic myeloid leukemia (CML); Molecular pathogenesis of CML; The BCR-ABL tyrosine kinase as a therapeutic target; Preclinical and clinical development of the ABL tyrosine kinase inhibitor, imatinib"

Immunobiology of HIV - (Henry Stewart Talks)

HIV molecular biology; HIV entry into cells; Immune consequences of HIV infection; Animal models of HIV infection; Immune containment of HIV; HIV vaccine development

Immunogenicity Problem in Antibody Therapy - (Henry Stewart Talks)

"Typical IgG antibodies; Features of an immunogenic antibody capable of eliciting antibody responses: foreignness, degradability, capacity to generate "danger" signals and aggregation; CD4 T-cells; Overcoming antibody immunogenicity"

Impact of Genomic Architecture and Diversity on Human and Infectious Diseases - (Henry Stewart Talks)

Genome complexity; Human genome; Human and mouse genome architectures; Genome correlations; Comparative genomics; Viral genomes and reverse vaccinology; Infectomics and virogenomics; Viral transcriptomes; Gene knockdown strategies

Importance of nucleotide size in the chemistry and biology of DNA - (Henry Stewart Talks)

Chemical and biophysical properties of size-expanded DNA bases (xDNA); Structure of xDNA; Design of benzo-widened DNA bases (yDNA); Non-polar nucleoside isosteres; Base pair replication without hydrogen bonds

Imputation methods for GWAS - (Henry Stewart Talks)

Tag SNPs and multi-marker predictors; The general problem of imputing genotypes for association studies; The IMPUTE method; Measuring accuracy of imputation; Results of using imputation in a real study; Using imputation for meta-analysis

Inborn Errors of Ketone Body Metabolism - (Henry Stewart Talks)

"Ketone body metabolism; Diagnostic approach; Defects in ketogenesis; Defects in ketone body utilization (succinyl-CoA:3-ketoacid CoA transferase deficiency, mitochondrial acetoacetyl-CoA thiolase deficiency)"

Infection and Autoimmunity: A Two-Way Relationship - (Henry Stewart Talks)

Viruses and autoimmunity; The role of HCV and HIV; Antiphospholipid syndrome and infections; Molecular mimicry; Infectious agents and antibodies to beta-2-glycoprotein I peptides

Infection and Chronic Disease - (Henry Stewart Talks)

"Chronic diseases (cystic fibrosis, atherosclerosis, tuberculosis); Risk factors; Primary and secondary causes; Categories of disease causation; Risk factors and disease causation; The e4 allele and the thrifty genotype hypothesis"

Infectious Environmental Factors and Systemic Lupus Erythematosus - (Henry Stewart Talks)

Etiology and genetics of SLE; Hormonal influences in SLE; Role of infections in SLE; Infections associated with lupus; Apoptosis in lupus; Infectious bystander effects in SLE; Development of autoantibodies in lupus; Epitope spreading

Inflammation and immune cell entry to the central nervous system - (Henry Stewart Talks)

Systemic infection and blood sepsis; Toll-like receptors and proinflammatory signaling in microglia; Brain diseases associated with inflammation; Innate immunity and neuroprotection

Influenza Virus Pandemics: Past and Future - (Henry Stewart Talks)

"Influenza virus, the agent and the disease; Epidemiology in humans and animals; The 1918 pandemic; Reconstruction of the extinct 1918 influenza virus in the laboratory; Highly pathogenic avian influenza virus; Future influenza pandemics"

Information Content in Sequences and its Relation to Protein Structure Prediction - (Henry Stewart Talks)

Concept of information; Variation in protein sequences; Patterns; Comparison with language; Measuring information; Genetic code; Correlated substitutions; Proteins' high tolerance for substitutions; Protein structure prediction

Information on untyped variation in genome-wide association studies - (Henry Stewart Talks)

Genome-wide association studies; Methods for testing untyped variation; Coverage of commonly used platforms; Multilocus linkage disequilibrium; TUNA: testing untyped alleles; Accuracy of imputation; Indirect methods for structural variation

Ingestive peptides - (Henry Stewart Talks)

Ingestive peptides; Transport across the blood-brain barrier; Relation to obesity; Control of transporter and implications for body weight control; Ghrelin and its relation to the blood-brain barrier and body weight control

Initiation of Protein Synthesis - (Henry Stewart Talks)

Main steps in translation initiation; Control of translation; Initiation factor modification; Competitive interactions for translational control; General versus gene-specific control

Innate Immunity and Natural Autoantibodies - (Henry Stewart Talks)

Host defense mechanisms; Innate immunity: first line of defense; Physiological autoreactivity; Autoimmunity; Immunological tolerance; Self-reactive B and T lymphocytes; Natural autoantibodies; Origins of natural autoantibodies

Innate Immunity to Retroelements by Human AID/APOBEC3 Proteins - (Henry Stewart Talks)

Nucleic acid basics; AID-related APOBEC3 proteins are DNA cytosine deaminases; Retrovirus (e.g. HIV and MLV) restriction by APOBEC3 proteins; Endogenous retroelement (e.g. Ty1 and L1) restriction by APOBEC3 proteins

Insertion sequences and DNA transposition - (Henry Stewart Talks)

"Insertions sequences; A major form of mobile genetic elements in eubacteria and archaebacteria; Insertion sequences move via DNA transposition; Insertion sequences cause genome changes (insertions, deletions, inversions and chromosome fusions)"

Insight and responsibility: ethics in pain medicine and palliative care - (Henry Stewart Talks)

"The nature of chronic pain, pain patients, and the system we practice in creates ethical issues for us all; Diagnosis: there are many painful diseases and pain diseases; What is pain?; Beginning to end: the chronic pain cycle"

InsP3 Receptor Calcium Release Channel - (Henry Stewart Talks)

The inositol trisphosphate receptor signaling system; Dynamic properties of cytoplasmic Ca2+ signals; Structural properties of the InsP3R; Patch clamp electrophysiology of the InsP3R channel; Permeation properties of the channel

InsP3 Receptor Calcium Release Channel - (Henry Stewart Talks)

The inositol trisphosphate receptor signaling system; Dynamic properties of cytoplasmic Ca2+ signals; Structural properties of the InsP3R; Patch clamp electrophysiology of the InsP3R channel; Permeation properties of the channel

Integrated Medical Curriculum (IMC)

Medical education courses developed from Gold Standard Multimedia's core collection medical education CD products with powerful Web search features. The IMC contains in-depth text coverage, animations, streaming audio and video, photos and illustrations, interactive quizzes, quality content and more.

Interaction of antibiotics with the large ribosomal subunit from Haloarcula marismortui - (Henry Stewart Talks)

Introduction to a paradox: how can a universally conserved cellular component be a target for pharmacologically useful antibiotics?; Introduction to ribosome structure; Antibiotic binding sites cluster in the ribosome

Intracellular Ca2+ Signaling: Calcium Influx - (Henry Stewart Talks)

Importance of intracellular calcium in cell activation; Sources of intracellular calcium; Key role for calcium channels in the plasma membrane; Voltageoperated calcium channels; Sub-types of voltage-operated calcium channels

Intravenous Immunoglobulins: Myth and Reality - (Henry Stewart Talks)

The use of intravenous immunoglobulins (IVIg) as therapeutic proteins; Use of IVIg to provide effective treatment for autoimmune thrombocytopenic purpura; Use of IVIg in a large range of autoimmune or systemic inflammatory diseases

Introduction to Cellular Calcium Signaling - (Henry Stewart Talks)

Introduction to the spatial and temporal complexity of cellular calcium signals; Calcium 'on' and 'off' mechanisms; The calcium signaling toolkit; Calcium sources; Calcium waves; Calcium oscillations; Cell-specific calcium signaling proteomes

Introduction to Chromatin Structure - (Henry Stewart Talks)

Chromatin and differential regulation of transcription; Basic structure and properties of a nucleosome; Current knowledge on higher order chromatin structures

Introduction to drug metabolizing enzymes - (Henry Stewart Talks)

Metabolism of lipophilic molecules; Phase I and Phase II enzymes; Location; Mechanism; Typical substrates; Genetic variation; Species variation; Inhibition and drug interactions; Drug design

Introduction to Flexible, Adaptive Clinical Trial Design - (Henry Stewart Talks)

Advantages of flexible clinical trials; Group sequential designs; Information based designs; Applications and logistical aspects of information based designs; Adaptive designs; Flexibility of the adaptive methods; Sample size computation

Introduction to free radicals and oxidative stress: the oxygen paradox - (Henry Stewart Talks)

"The oxygen paradox; Oxygen origin; Free radicals, oxidants and oxidative stress; Sources of free radicals; Environmental toxins; Metabolic sources of free radicals: mitochondrial electron transport, phagocytes, peroxisomes, autooxidation"

Introduction to plasmid biology - (Henry Stewart Talks)

Ubiquity of plasmids; The prokaryotic world; Conjugation; Common traits encoded by plasmids; Conformation; Maintenance; Classification; Higher systems

Introduction to Population Genetics 1: Single Locus - (Henry Stewart Talks)

Concepts in population genetics; Wright-Fisher model; Drift; Effective population size; Mutation-drift equilibrium; Population structure; Selection; Hardy-Weinberg equilibrium; Coalescent theory

Introduction to Population Genetics 2: Linkage Disequilibrium - (Henry Stewart Talks)

Overview of part 1; Two-locus Wright-Fisher model; Ancestral Recombination Graph (ARG); Measures of LD; Disease-marker association; LD due to linkage; LD due to admixture; Haplotype sharing; LD in human populations: empirical studies; Haplotype blocks

Introduction to Retroviruses: Replication Strategy and Genetics - (Henry Stewart Talks)

Retroviruses; Life cycle; Classification; Simple and complex retroviruses; Endogenous retroviruses; Retroviruses and cancer

Introduction to the Eukaryotic Gene Regulation Series - (Henry Stewart Talks)

Introduction to the series by Professor Michael Carey and Professor Stephen Smale

Introductory Genetics for Statisticians - (Henry Stewart Talks)

Physical basis of the human genotype; Meiosis; Genotype vs. phenotype; Genetic distance; Mendelian segregation; Dominance and recessiveness; Hardy-Weinberg proportions; Heritability (broad sense and narrow sense); Additive polygenic models

Intron Splicing of Pre-mRNA: The Spliceosome - (Henry Stewart Talks)

"Recognition of splice junction sequences by components of the spliceosome; Spliceosome assembly, catalysis and disassembly; Roles of snRNPs as well as non-snRNP components; RNA dependent ATPases; Splicing in creating multiple mRNAs"

Investigation of stroke - (Henry Stewart Talks)

Systematic approach to diagnosis of stroke; Stroke mimickers; Differential diagnosis of stroke mechanisms; General approach to investigation of stroke; Case examples

In-vitro models of the blood-brain barrier - (Henry Stewart Talks)

Blood-brain barrier; In vitro models of blood-brain barrier; Blood-brain barrier permeability; Brain endothelium and tight junctions; Transporters at the blood-brain barrier

In-vivo systems - (Henry Stewart Talks)

Common issues in brain uptake assessment; Multiple factors impact brain delivery and exchange; Assumptions; What information is sought?; What brain compartment is appropriate?; Brain transport kinetics; In vivo methods to assess BBB transport

Ion transport - (Henry Stewart Talks)

Ischemic stroke; Mechanisms of cerebral edema formation; Brain microvascular endothelial cell ion transporters and channels; Role of blood-brain barrier in water and electrolyte homeostasis in the brain

Ischemic blood-brain barrier and Alzheimer's amyloid plaques development - (Henry Stewart Talks)

Ischemic blood-brain barrier involved in Alzheimer's amyloid plaques development and full-blown Alzheimer's disease; Brain ischemia starts Alzheimer's disease; Association and risk factors for Alzheimer's disease