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Macromolecular Crowding and Protein Aggregation - (Henry Stewart Talks)

The principle of protein self-assembly; Discovery of proteins binding to newly synthesized polypeptides; Discovery of the chaperonins; Origins of the molecular chaperone concept; Replacement of spontaneous self-assembly by assisted self-assembly

Major Gene Families in Humans and their Evolutionary History - (Henry Stewart Talks)

Multigene family; Olfactory Receptors (ORs); OR genes in humans; Comparison of OR genes between humans and mice; Evolution of OR genes in vertebrates; Other chemosensory receptor genes

Mammalian microRNA Assembly and Function - (Henry Stewart Talks)

"miRNAs and RNA interference, nuclear biogenesis and cytoplasmic processing; siRNA biogenesis and assembly; Silencing by target mRNA cleavage and "translational repression"; RISC assembly in flies; RISC activity and Dicer"

Mapping Motivations: Evolutionary Health Promotion - (Henry Stewart Talks)

"Most of today's health problems can be prevented by changes in behavior; How understanding behavior, and behavioral motivation in particular, from an evolutionary perspective can provide new avenues for health promotion"

Mapping small molecule binding sites with phage display technology - (Henry Stewart Talks)

How do you identify the molecular target of a small molecule drug?; Flexible regions are key players; P-loop of ATP-binding proteins is an important example; Can display libraries of flexible peptides on proteins select those that bind to the ligand

Materials for Tissue Engineering - (Henry Stewart Talks)

Range of materials considered for tissue engineering; Research into cell-material interaction; Development of new technologies; Highly tailored biomaterials: role in guiding cell behaviour and tissue regeneration; Medical implants

Mechanism of chaperone action of small heat shock proteins - (Henry Stewart Talks)

Small HSP diversity and evolution; Biological roles of sHSPs; sHSP structure and oligomeric assembly; Model of sHSP chaperone activity; sHSP oligomer dynamics; sHSP substrate interactions; Testing sHSP function in vivo

Mechanism of prion generation in vitro - (Henry Stewart Talks)

Prion propagation in vitro requires PrP plus an incorporated polyanion; PrPC post-translational modifications influence prion formation; Zinc and copper inhibit PrPSc amplification

Mechanism of translocon function: current insights and models - (Henry Stewart Talks)

Bacterial protein sorting; Evolutionary conserved translocons; Structure of SecYEG complex; Oligomeric assemblies of the SecYEG complex; Oligomeric state of the active SecYEG complex; Orientation of the SecYEG in dimeric complexes

Mechanism-Based Therapies for Heart Failure and Cardiac Arrhythmias - (Henry Stewart Talks)

Intro to excitation-contraction coupling; History of the field of EC coupling; Introduction to the ryanodine receptor/calcium release channel (RyR2); Mechanisms that regulate the RyR2 channel during stress; Defective regulation of RyR2 in heart failure

Mechanisms and Applications of siRNA Mediated Transcriptional Gene Silencing in Human Cells - (Henry Stewart Talks)

How siRNAs mediate transcriptional gene silencing (TGS) in human cells; Histone methylation; Dependency on active RNA polymerase II mediated transcription; siRNA-mediated TGS; H3K9 and H3K27 methylation of the targeted EF1A promoter

Mechanisms and Control of mRNA Turnover in Eukaryotic Cells - (Henry Stewart Talks)

Control of mRNA degradation; Modulation in response to physiological cues; Mechanisms of mRNA turnover; Critical nucleases; Sequence-specific binding of regulators; Rates of turnover; mRNA decay and viral infections; Role in recognizing aberrant mRNAs

Mechanisms and Regulation of Protein Degradation in Cells - (Henry Stewart Talks)

"Protein levels in cells are regulated by their rates of synthesis and degradation; Regulatory proteins are rapidly degraded by the ubiquitin-proteasome pathway; Examples include many oncogenes, transcription factors and cyclins"

Mechanisms of androgen receptor function in reproduction and cancer - (Henry Stewart Talks)

Mechanisms of androgen action; Biological basis for androgen potency; Androgen receptor FXXLF motif and N/C interaction; Androgen receptor coactivator melanoma antigen gene protein-11

Mechanisms of Apoptosis from Structural Biology - (Henry Stewart Talks)

Structural mechanism of IAP recognition by Smac/DIABLO; Structural mechanism of caspase-9 inhibition by XIAP-BIR3; Structural mechanism of effector caspase inhibition by XIAP; Structural mechanism of initiator caspase activation

Mechanisms of Mitochondrial Fusion and Fission - (Henry Stewart Talks)

Mitochondrial ultrastructure; Mitochondrial organization in the cytosol; Mitochondria-shaping proteins; Dynamins and the dynamin superfamily; Control of mitochondrial shape in yeast; Control of mitochondrial morphology in mammals

Mechanisms of Protein Folding Reactions - (Henry Stewart Talks)

History of protein folding; Origin of complexity in protein folding kinetics; Slow reactions coupled to folding; Prolyl isomerization; Non-prolyl isomerization; Association reactions; Detection of folding intermediates

Mechanisms of Transcription and Function of RNA Polymerase in Eukaryotes - (Henry Stewart Talks)

Chromatin remodeling for transcription; The RNA polymerase II transcription machinery; Mediator of transcriptional regulation; Atomic structure of RNA polymerase II and of a transcribing complex

Mechanisms of Transcription: The Eukaryotic Pre-Initiation Complex - (Henry Stewart Talks)

Overview of RNA polymerase II transcription; Core promoter elements; Proximal promoters; Enhancers and silencers; General transcription factors; Activators and repressors; Coactivator complexes; RNA polymerase II structure and function

Mechanisms of yeast prion propagation - (Henry Stewart Talks)

Prions as infectious amyloids; Yeast [PSI+] prion and Sup35p; Molecular chaperone Hsp104; Guanidine hydrochloride as a prion propagation inhibitor; Propagons; Estimating propagon numbers using a stochastic model

Mechanistic Aspects and Therapeutic Applications of RNAi - (Henry Stewart Talks)

RNAi mechanisms; RNAi and HIV infection; Lentiviral vector-mediated transduction of stem cells and T-cells; Gene therapy based treatment of HIV-1; HIV mutants that abrogate RNAi; Multiplexing different siRNAs and siRNAs with other antiviral RNAs

Mechanistic aspects of chaperonin GroEL/ES function - (Henry Stewart Talks)

Chaperonin structure; The allosteric mechanism of GroEL coupling between GroEL allostery and folding; The unfoldase activity of GroEL; The GroE reaction cycle

Medical and surgical stroke - (Henry Stewart Talks)

Cerebrovascular complications of medical interventions and invasive procedures; Cardiac catheterization and cerebral embolism; Risk factors for stroke and patterns of cerebral damage during cardiac surgery

Medical Grand Rounds

Links to UCHC Medical Grand Rounds

Medical therapy for secondary prevention of ischemic stroke - (Henry Stewart Talks)

"Risk of recurrent stroke; Lifestyle modification; Platelet antiaggregant therapy; aspirin, clopidogrel, aspirin plus sustained-release dypiridamole; Antihypertensive therapy; Lipid lowering therapy"

MedPix (Medical Image Database)

MedPix is a free online Medical Image Database, provided by the Departments of Radiology and Biomedical Informatics, Uniformed Services University, Bethesda, MD. All public content is peer-reviewed by an Editorial Panel. MedPix provides the indexing, storage service, and bandwidth as a public education service.

Membrane Transport from the Endoplasmic Reticulum - (Henry Stewart Talks)

Evolutionary origin of the ER; Role of the ER in membrane biogenesis; Export from the ER in COPII transport vesicles; Clustering of COPII components at transitional ER sites; Relationship between ER export and the Golgi apparatus

Mendelian randomisation to explore causality - (Henry Stewart Talks)

Ischaemic heart disease; Valvular heart disease; Heart muscle disease; Monogenic form of common disorder; Single gene disorders and cardiovascular disease; Mutation both necessary and sufficient to lead to disease; Genetic basis of the common form of CHD

Menopausal hormone therapy - (Henry Stewart Talks)

Menopause health risks; Hormone therapy in perspective; Reasons for continuing or initiating ERT/HRT; HRT benefits; Women's health initiative (WHI); Heart disease; Effect of Estrogen on risk of CHD; Breast cancer

Mental Disorders in the Light of Evolutionary Biology - (Henry Stewart Talks)

Psychiatry is just now recognizing the need for evolutionary explanations; Same six origins of vulnerability as the rest of medicine; Emotional disorders are dysregulated defenses; Research and treatment implications

Meta-analysis of GWAS - (Henry Stewart Talks)

Genetic architecture of common complex diseases; Genome-wide association scans; Genome-wide association scan methodology; Application to type 2 diabetes genome-wide association scan data

Metabolic, Adipose Tissue and Muscle Predictors of Obesity - (Henry Stewart Talks)

Components of energy metabolism; Aerobic fuels; Energy and substrate balance; Partitioning of energy expenditure; Adipose tissue; Skeletal muscle; Metabolic disturbances in obesity

Metachromatic Leukodystrophy - (Henry Stewart Talks)

Metabolic defect in metachromatic leukodystrophy; Genetics; Genotype/phenotype correlations; Biochemical consequences of selected mutations; Diganostic problems due to arylsulfatase A pseudodeficiency

Metals, Oxidative Stress and Neurodegeneration - (Henry Stewart Talks)

Production of reactive oxygen species (ROS); Chemical origin; Generic mechanism of protein and transition metal combination; Pathological protein aggregates; Toxic ROS generation

Metastasis of Drosophila tumors - (Henry Stewart Talks)

"Recessive lethal mutations of Drosophila cause brain tumors that are metastatic; Despite their apparent similarities, tumors caused by different mutations have different metastatic properties"

Methyltransferases - (Henry Stewart Talks)

"Properties, structure, catalytic cycle, isoforms and drug substrate specificity of the main methyltransferase families contributing to drug metabolism; Regulation of gene expression; Pharmacogenetics"

microRNA function in stem cells - (Henry Stewart Talks)

microRNAs; Stem cells; Stem cell cell cycle; Stem cell checkpoints; p21; hESCs; Stem cell self-renewing division; Notch; Niche

Miracle of morphogenesis, cell adhesion, polarity and cytoskeletal regulation - (Henry Stewart Talks)

Self-assembly of cells into tissues and organs; Understanding this process from the molecular to whole animal level; Different cell types; Cell adhesion; Epithelial sheets; Drosophila cell adhesion; Gastrulation; Cadherin expression

Mitochondria in Apoptosis - (Henry Stewart Talks)

Cell death; Apoptosis; Mitochondria; Mitochondrial membrane permeabilization; Bcl-2; Bax; Permeability transition pore; Cytochrome c; Mechanistic explanations; Cancer; Degenerative diseases

Mitochondrial Biogenesis as a Result of Exercise - (Henry Stewart Talks)

Mitochondrial reticulum in skeletal muscle; Biochemical adaptations to activity; Transcriptional activation of exercise responsive genes; Influence of exercise intensity and duration; Principles of protein turnover; Kinetic basis of training adaptations

Mitochondrial Biogenesis during Gametogenesis and Embryonic Development - (Henry Stewart Talks)

Mitochondrial biogenesis and mass; Mitochondrial biogenesis in spermatogenesis; Mitochondrial biogenesis in oogenesis; The bottleneck theory; Maternal transmission of mitochondrial DNA; Influence of the mitochondrial DNA content on fertilization

Mitochondrial Complex Assembly - (Henry Stewart Talks)

"The mitochondrial oxidative phosphorylation system; Components: mitochondrial subunits, nuclear subunits and prosthetic groups; Coordination of assembly; Factors involved in assembly; Defects in OXPHOS assembly; Complex IV assembly; Complex I assembly"

Mitochondrial Diseases: An Update - (Henry Stewart Talks)

Mitochondrial functions; Energy generation via oxidative metabolism; The respiratory chain; Mitochondrial DNA (mtDNA); Mitochondrial genetics; A genetic classification of the mitochondrial diseases; Diseases due to mutations in mtDNA

Mitochondrial Disorders and Neurodegeneration - (Henry Stewart Talks)

Spectrum of mitochondrial diseases; Mitochondrial metabolic pathway; MtDNA mutations and disease; Pathological features; MELAS; Genetic epidemiology of mtDNA mutations; Structural components of respiratory chain complexes; Mitochondrial DNA metabolism

Mitochondrial Disorders and Neurodegeneration - (Henry Stewart Talks)

Spectrum of mitochondrial diseases; Mitochondrial metabolic pathway; MtDNA mutations and disease; Pathological features; MELAS; Genetic epidemiology of mtDNA mutations; Structural components of respiratory chain complexes; Mitochondrial DNA metabolism

Mitochondrial DNA Replication and Transcription - (Henry Stewart Talks)

Introduction to the mitochondrial genetic system; Features of mammalian mitochondrial DNA; Characteristics of mitochondrial genetics; Mitochondrial DNA replication: strand-displacement and strand-coupled models

Mitochondrial Fatty Acid Oxidation Deficiencies - (Henry Stewart Talks)

"Mitochondrial fatty acid oxidation (FAO) defects; FAO biochemical pathways; FAO defects; Diagnosis of FAO defects; Newborn screening for FAO defects, especially medium-chain acyl-CoA dehydrogenase (MCAD) deficiency"

Mitochondrial Heterogeneity in Cells - (Henry Stewart Talks)

Levels of mitochondrial heterogeneity; Subcellular heterogeneity; Membrane potential; Permeability transition; Calcium uptake; Morphology: network or discrete?; Live cell mitochondrial 3D reconstruction; Fluorescence Recovery After Photobleaching (FRAP)

Mitochondrial Myopathies: Exercise and Nutrition - (Henry Stewart Talks)

Mitochondrial biology; Clinical features in diagnosis of mitochondrial disorders; Morbidity map and inheritance patterns; Clinical features and causes of fatigue with mitochondrial impairment; Mitochondrial diagnosis

Mitochondrial Pathway in Apoptosis - (Henry Stewart Talks)

Apoptosis and programmed cell death; Apoptosis occurrence and induction; Role of caspase proteases in apoptosis; Apoptotic pathways in mammals; Mitochondrial pathway of apoptosis; The Bcl-2 family proteins; Mitochondrial permeability transition