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Nanotechnology for Tissue Engineering - (Henry Stewart Talks)

Nanomedicine; Nanotechnology; Tissue engineering; Orthopaedics; Cartilage; Vascular; Bladder; Central and peripheral nervous system

Natural Caspase Inhibitors - (Henry Stewart Talks)

Apoptosis; Proteolytic mechanisms; Caspases; Activation mechanisms; Natural caspase inhibitors; Viral inhibitors; IAPs; Inhibitory mechanisms; IAP antagonists; Theory of activating apoptosis by de-repression of caspase inhibition

Natural History and Pathogenesis of Herpes Virus Infections - (Henry Stewart Talks)

Herpes viruses: the family; Natural history; Clinical manifestations of herpes simplex infections; Seroprevalence of HSV-1; Seroprevalence of HSV-2; The pathogenesis of primary infection with varicella zoster virus (VZV); Complications of herpes zoster

Natural Selection and Sequence Polymorphism - (Henry Stewart Talks)

Inferring selection from patterns of nucleotide substitution; The Major Histocompatibility Complex as an example of positive selection; Immunodeficiency virus escapes from immune recognition; Purifying selection on Single Nucleotide Polymorphisms

Nature of Chemical Neurotransmission - (Henry Stewart Talks)

Chemical neurotransmission; What is a neurotransmitter?; Neurotransmission: mechanism of action; Mechanisms governing neurotransmitter release; Different types of receptor; Switching off neurotransmitters; Synthesis and metabolism of acetylcholine

Nature, Nurture, Neither? - (Henry Stewart Talks)

Do genes matter?; The interplay of genes and the environment; Lessons from Eugenics; Case studies: human and other relatives; The legal implications

Networks and Global Gene Expression - (Henry Stewart Talks)

A paradigm shift: from databases of protein sequences to protein interactions; Technologies for measuring interactions; Chromatin immunoprecipitation (ChIP); Yeast Two Hybrid (Y2H) technology; Mass spectrometry based approaches

Neural Control of Food Intake and Energy Balance - (Henry Stewart Talks)

Sensing nutrients in the alimentary canal; Sensing absorbed nutrients; Hindbrain control of meal size; Hypothalamic control of energy balance; Environmental influences on body weight regulation; Cognitive controls of food intake; Food as reward

Neuroimaging in Dementia: Using MRI in Routine Work-Up - (Henry Stewart Talks)

Changing role of structural imaging in dementia; Current diagnostic use; Sensitivity and specificity; Identifying biological markers for disease; Examples from clinical practice

Neuronal Calcium Sensor Proteins: Calcium Sensors and Regulators of Diverse Cellular Functions - (Henry Stewart Talks)

Introduction to calcium sensors; The neuronal calcium sensor (NCS) protein family; The calcium/myristoyl switch; Dynamics of hippocalcin translocation; Specific localization of NCS proteins; Functions of NCS-1; Hippocalcin in synaptic plasticity

Neuronal Ceroid Lipofuscinoses - (Henry Stewart Talks)

Clinical features of the neuronal ceroid lipofuscinoses; Genetics; Genotype/phenotype correlations; Protein epidemiology; Mechanisms of neurodegeneration; Treatment approaches

Neuropathology of Neurodegenerative Disorders - (Henry Stewart Talks)

Current neuropathological diagnostic criteria for neurodegenerative disorders; Major macroscopic and microscopic features; Pattern and extent of brain atrophy; Alzheimer's disease; Lewy body diseases; Frontotemporal dementia; Other tauopathies

Neurotransmitter Receptor Variants and Psychotropic Drugs - (Henry Stewart Talks)

Neurotransmitter receptors and biological interactions; Genetic mutations; Influence on receptor function; Drug targeted receptors; Dopamine variants; Serotonin variants; Adrenergic variants; Muscarinic variants; Histamine variants

Neurotrophins/cytokines and the blood-brain barrier - (Henry Stewart Talks)

Overview of neurotrophins; CNS physiology and roles in neuroregeneration; The blood-brain barrier (BBB); General strategies to enhance CNS delivery; Progress on neurotrophin delivery across the BBB; Limitations and future directions

New Designs for siRNAs as Dicer Substrate - (Henry Stewart Talks)

"Potency of RNA duplexes of ~27 nucleotides in length; Dicer substrates; Variation in dicing patterns; Defined substrate preferences for Dicer; Design of RNA duplexes that are processed to specific, desired products"

New Standards in Weight Management: Recent and Future Drugs for the Treatment of Obesity - (Henry Stewart Talks)

Pharmacotherapy as target for 5 to 10 % weight loss option; Pharmacotherapy as an additional approach for weight management programs; Characteristics of appropriate anti-obesity agents; Actual experience with anti-obesity agents

New Strategies to Prevent Transplant Rejection: From Molecules to Mice to Monkeys to Man - (Henry Stewart Talks)

Clinical transplantation; Current immunosuppression; T-cell activation; Co-stimulatory pathways; CD28 pathway; Mechanisms of action and clinical development; CD40-CD154 pathway

N-of-1 Randomized Clinical Trials - (Henry Stewart Talks)

History and impact of N-of-1 RCTs; Distinguishing N-of-1 RCTs: case studies and time series research; The funnel approach to measurement; The randomized experimental approach; Types of N-of-1 designs and replications

Non HIV Antivirals - (Henry Stewart Talks)

"Pharmacokinetics and clinical application of antiviral agents excluding antiretrovirals for HIV; The therapeutic and prophylactic options for herpes infections including herpes simplex 1 and 2, varicella zoster and cytomegalovirus"

Non-P450 oxidative metabolism: characteristics and drug substrates - (Henry Stewart Talks)

"Cytosolic, mitochondrial and microsomal enzymes in drug oxidation; Molybdoflavoproteins; Aldehyde oxidase; Xanthine oxidase; NAD(P)-dependent aldehyde dehydrogenase; NAD+-dependent alcohol dehydrogenase; Monoamine oxidase"

Nonparametric Covariate Adjustment - (Henry Stewart Talks)

"Common parametric and semiparametric approaches for adjusting for covariates, including analysis of variance (ANOVA) and analysis of covariance (ANCOVA); Assumptions underlying their validity; Nonparametric version of the ANOVA model"

Normal Sequence Pathogenic Proteins Contribute to Risk of Disease - (Henry Stewart Talks)

Protein pathology of disease; Loci underlying autosomal dominant neurodegenerative disease; Prion mutations causing Gerstmann Straussler syndrome and hereditary Creuzfeldt-Jakob disease; Tau mutations cause autosomal dominant frontal temporal dementia

Novel Approaches to Diagnosis of Viral Infections - (Henry Stewart Talks)

Mechanisms of microbial pathogenesis; Proof of causation; Strategies for pathogen surveillance and discovery; Future perspectives for investigating links between infection and acute and chronic diseases

Novel Aspects of Systemic Sclerosis - (Henry Stewart Talks)

Systemic sclerosis: clinical heterogeneity; Classification vs. diagnosis of the disease; Diagnosing early disease; Clinical and serologic subsetting; Assessment of the extent of organ involvement; Assessment of disease activity and severity

Novel Immunotherapeutic Proteins: Immunoligand - (Henry Stewart Talks)

Potential advantages of mAB; Challenges for mAB; Antibody based therapeutic proteins; Attributes of immunoligands; Creation of Ig-based fusion proteins; Non-cytolytic IL-2/Fc fusion protein; Vaccine trial design

Novel Methods for Randomizing - (Henry Stewart Talks)

Obstacles to standard methods of restricted randomization; Biased coin methods; Nash equilibrium; The maximal procedure; Covariate adaptive methods; Response adaptive randomization; Predictability and the potential for selection bias

Novel Proteins from Designed Combinatorial Libraries - (Henry Stewart Talks)

Novel proteins can be devised using either rational/computational approaches or random/combinatorial methods; Description of a hybrid approach that combines rational and combinatorial methods: libraries of novel proteins; Combinatorial diversity

Nuclear Calcium Signaling - (Henry Stewart Talks)

"Nuclear calcium signaling, an intriguing history of the last 10 years of research and promising recent developments with the emphasis on fluorescent confocal techniques; Basic features and major consensus on principles"

Nuclear Cloning, Stem Cells and Epigenetic Reprogramming - (Henry Stewart Talks)

"Transfer of somatic cell nuclei into enucleated oocytes for full term development of mammals; genomic reprogramming; the use of ES cells, terminally differentiated lymphoid cells, neurons and cancer cells as donors for nuclear transplantation"

Nuclear Control of Respiratory Chain Expression by Transcriptional Activators and Co-Activators - (Henry Stewart Talks)

Contribution of nuclear and mitochondrial genomes to respiratory chain expression; Genomic origin of respiratory chain subunits; Cytochrome c as a model for respiratory gene expression

Nuclear Organization and Gene Expression - (Henry Stewart Talks)

"Current understanding of the organization of the mammalian cell nucleus and how this organization impacts on gene expression; in-vivo studies of gene expression as a result of the concerted processes of transcription, mRNA processing"

Nuclear Organization and Gene Expression - (Henry Stewart Talks)

"Current understanding of the organization of the mammalian cell nucleus and how this organization impacts on gene expression; in-vivo studies of gene expression as a result of the concerted processes of transcription, mRNA processing"

Nuclear receptor superfamily: structural insights into function - (Henry Stewart Talks)

Signal transduction and transcriptional regulation; Cofactor binding and transcriptional activation; The modular organization of nuclear hormone receptors; The DNA binding domain; The ligand binding domain; Sequence/structure to function

Nuclear receptors: transcriptional functions - (Henry Stewart Talks)

Introduction to transcription factors; Nuclear receptors as ligand-dependent transcription factors; Classes of nuclear receptor; Nuclear receptor ligands: agonists and antagonists; Nuclear receptor phylogeny; Nuclear receptor isoforms

Nucleosome Dynamics and Remodeling - (Henry Stewart Talks)

Chromatin composition; Nucleosome structure and function; Dynamic properties inherent to nucleosomes; Invasion of nucleosomes by gene regulatory proteins; DNA binding proteins and enzymes; ATP dependent remodeling factors; Nucleosome relocation