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Obesity and Mortality: Questions and Controversy - (Henry Stewart Talks)

Relationship between obesity and mortality rate is complex; Differences in associations and causal effects may exist both within and across species; Obesity is clearly associated with elevated mortality rate

Obesity, Diabetes and the Cluster of the Metabolic Syndrome - (Henry Stewart Talks)

"The effect of diabetes, obesity and overweight on risks for heart disease; Framingham Heart Study analyses; The effects in men and women; Metabolic studies of new diabetes; Population studies"

Obesity, Dyslipoproteinemia and Inflammation - (Henry Stewart Talks)

"Normal lipid and lipoprotein physiology; Abnormalities of lipid and lipoprotein physiology in obesity and related mechanisms; Inflammation and obesity; Benefit of weight reduction to favorably modify plasma lipids, lipoproteins and the inflammatory burden"

Obesity, Weight Loss and Health-Related Quality of Life - (Henry Stewart Talks)

"Obesity: research and clinical practice; Quality of life: functioning and wellbeing; Physical, mental, social and obesity-specific perspectives; Health-related quality of life (HRQOL); Questionnaires; Disease-specific measure of HRQOL"

Obesity: Socio-Cultural, Built Environment and Economic Factors - (Henry Stewart Talks)

"Rapid increases in obesity prevalence globally; Increases in obesity among immigrants; Socio-cultural influences: human relationships and interactions, attitudes, norms and values and social structure; "Built environment" influences"

Occupational and Environmental Influences on the Development and Course of Lupus - (Henry Stewart Talks)

Role of genetic susceptibility in the etiology of systemic lupus erythematosus (SLE); Demographic risk factors for SLE; Epidemiologic and experimental research on occupational exposures (respirable silica dust and solvents) and risk of developing SLE

Opening the Pathway to Current, Effective Antiretroviral Therapy - (Henry Stewart Talks)

The early recognition of the AIDS epidemic; Initial speculation regarding the cause of AIDS; The discovery of HIV; Initial efforts to treat AIDS using first generation antiretrovirals; Improved potency of therapy with combinations of three active drugs

Opioid receptor pharmacology and pain - (Henry Stewart Talks)

Opioid receptors: relevance; Opioids in pain management; Opioid analgesics: pharmacology; The endogenous opioid system; Endogenous opioid peptides; Effector systems; Opioid receptor activation; Opioid receptor mediated effects

Optimal treatment of chronic pain - (Henry Stewart Talks)

Dealing with the difficult and complex non-malignant pain patient; It is important to recognize both psychosocial and psychiatric co-morbidities; Having the patient become part of the solution and having them set realistic goals is important

Optimal Use of Linkage Disequilibrium, Haplotypes, and Integrated Maps for Positional Cloning - (Henry Stewart Talks)

The use of LD for localization of disease genes; The evolutionary theory behind LD maps; Comparison of alternative metrics and genetic models; Effect of SNP selection on power; Extension to haplotype analysis

Organellar Calcium Pumps of the Golgi and ER: From Yeast to Human - (Henry Stewart Talks)

Early and current views on Calcium signaling; Phylogenetic tree of Calcium-ATPases; Identification of a new family of Golgi/secretory pathway Calcium-ATPases (SPCA); Why have a Calcium pump in the Golgi?; Yeast as a model to understand Golgi Calcium pumps

Origin and Molecular Evolution of the Plastid - (Henry Stewart Talks)

"Plastid distribution in eukaryotes; Tree of life; Evidence for plastid origin through endosymbiosis; Primary, secondary and tertiary endosymbiosis; Organelle genome evolution; Endosymbiotic gene transfer; Dating the origins of plastids"

Original Human Diet: What was it and should it be a Model for Contemporary Nutrition? - (Henry Stewart Talks)

Human evolution; Contemporary genetic-lifestyle discordance; Ancestral nutrition as a model for the present; Current American nutrition; Successes (life expectancy) and failures ('afflictions of affluence'); The paradigm concept

Overview of eukaryotic molecular chaperones in the cytosol - (Henry Stewart Talks)

Protein folding and molecular chaperones; Hsp70/Hsc70; Co-chaperones of Hsc70; Chaperonin TRiC/CCT; Prefoldin; Hsp90; Co-chaperones of Hsp90; Specialized co-chaperones; Heat shock protein chaperones

Overview of Gene Regulation - (Henry Stewart Talks)

"General ideas behind DNA association with: histones, replication, transcription, splicing, RNA modifications, protein synthesis and death and global gene expression analysis"

Overview of prokaryotic molecular chaperones - (Henry Stewart Talks)

Protein folding in vitro versus in vivo; Concept of a molecular chaperone; Chaperones in E. coli; Trigger factor; DnaK/DnaJ/GrpE system; GroEL/GroES system; Clp ATPases

Overview of Protein Synthesis - (Henry Stewart Talks)

"Composition of the ribosome; Principle of translation; The four phases of translation; Structure and function of small and large ribosomal subunits; Role of elongation factors; The paths of messenger RNA, transfer RNA and the nascent polypeptide"

Overview of protein synthesis on the ribosome - (Henry Stewart Talks)

"The understanding of heredity and translation of proteins based on the genetic information; Intensive structural studies of ribosomes, tRNAs and translation factors; A historical overview; Main components of translation"

Oxidative modification of brain proteins in Alzheimer's disease and models thereof: role of amyloid beta-peptide (1- 42) and insights from redox proteomics - (Henry Stewart Talks)

"Alzheimer's disease and mild cognitive impairment; Oxidative stress markers in brain, including markers for protein oxidation and lipid peroxidation; Amyloid beta-peptide-mediated oxidative stress and Alzheimer's disease"

Oxidative stress and disease: atherosclerosis - (Henry Stewart Talks)

"Association of oxidative stress, chronic inflammation and fibrosis; Oxidative modification of LDL lipid moiety; Oxidative stress and cholesterol; Oxysterols and atherosclerosis; 4-Hydroxynonenal and atherosclerosis"

Oxidative stress in aging - (Henry Stewart Talks)

"Characteristics of aging; The decay of aging: cellular, tissue and organism level; The longevity curves: maximum and average life span; The theories of aging; The free radical theory of aging; Mitochondrial damage; Markers of oxidative stress in aging"

Oxidative stress in ALS - (Henry Stewart Talks)

Key facts; The normal human motor system; Motor neurone disease: clinical consequences; Spared motor neurone groups; Prognosis; Features of motor neurones which may underlie selective vulnerability; Complex and multifactorial disease

Oxidative stress in development and neonatal diseases - (Henry Stewart Talks)

Cellular effects of oxygen radicals; Sources of ROS; Hyperoxia; ROS in various processes; ROS: good or bad?; Important antioxidants; Antioxidant vitamins; Less traditional antioxidants; HO-1 gene; Nitric oxide; ROS and Down syndrome

Oxidative stress in disease: cardiac ischemia/reperfusion injury - (Henry Stewart Talks)

Reperfusion injury; Oxygen radicals are mediators of injury; Reperfusion radical generation and duration of ischemia; SOD1 and reperfusion; Xanthine oxidase as a source of radical generation; Xanthine oxidase substrates are formed during ischemia

Oxidatively generated damage to DNA: mechanistic aspects and formation in cell - (Henry Stewart Talks)

"Oxidation reactions; Main degradation pathways of nucleobases induced by OH radical, one-electron oxidants and singlet oxygen; Cellular DNA damage; Chromatographic and biochemical assays aimed at measuring damage in cells"