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Tagged library for chemical genetics - (Henry Stewart Talks)

"Chemical genetics is defined as "genetic" study using "chemical" tools; The key challenge in chemical genetics is target identification; Tagged library has been developed and demonstrated in this lecture to address the problem"

Target Selection and siRNA Designs - (Henry Stewart Talks)

siRNA target and off-target activity; Systematic analysis of siRNA primary function; Effect of thermodynamic bias on siRNA activity; Development of predictive algorithms for siRNA primary activity; Specific and non-specific siRNA activity

Targeting Apoptosis Pathways in Cancer Therapy: From Molecules to Therapeutics - (Henry Stewart Talks)

Apoptosis in cancer; Apoptosis signalling pathways; Death receptor pathway; Mitochondrial pathway; Targeting the death receptor pathway; Bcl-2 family proteins: structure and function; Targeting Bcl-2 family proteins; IAPs: structure and function

Targeting cancer: designing drugs against Hsp90 - (Henry Stewart Talks)

"Heat shock protein 90 (Hsp90), a target in cancer; Discovery of the first known Hsp90 inhibitor, geldanamycin; Use of geldanamycin to understand the role of Hsp90 in malignant transformation; Discovery of novel Hsp90 inhibitors"

Thalamo-cortical pain mechanisms - (Henry Stewart Talks)

Areas of the brain stimulated by different kinds of pain stimuli; Mechanisms of activation in the thalamus and cortex; The spinothalamic tract; Physiological differences between different parts of the spinothalamic tract

The Role of Stress and Immune System in Psychiatric Disorders - (Henry Stewart Talks)

The relationship between neurotransmitters and the HPA axis; The role of stress in psychiatric disorders; Effects of stress or depression on the HPA axis and the immune system; The role of the immune system in psychiatric disorders

Therapeutic Delivery of RNAi - (Henry Stewart Talks)

RNAi therapeutics development; RNAi cellular activity; In vivo siRNA delivery is key; Clinically viable siRNA deliveries; Local delivery of siRNA; Gene silencing in tumors; Cancer target validation in vivo

Therapeutic Options for Cancer Therapy: Targeting the Apoptosis Pathways - (Henry Stewart Talks)

Apoptosis pathways; Pathways regulating the intrinsic and extrinsic pathways; ovel therapeutic agents in cancer therapy that target the apoptosis pathways and the modulators of apoptosis

Therapy in cancer 2008: quo vadis? - (Henry Stewart Talks)

Why pursuing new therapeutic approaches in cancer is important; Prevention and screening; Current cancer therapy: non-surgical; Most chemotherapy targets DNA; Chemotherapy effects; Current state of cancer therapy: efficacy and toxicity

Thrombotic risk factors for cardiovascular disease - (Henry Stewart Talks)

Thrombosis: arterial and venous; Processes in thrombosis; Platelets; Coagulation; Coagulation factors; Coagulation Inhibitors; Coagulation activation markers; Fibrinolysis

Thyroid Hormone and Mitochondrial Biogenesis - (Henry Stewart Talks)

Synthesis of thyroid hormone (TH); Local bioavailability; Conversion of thyroxine by deiodination; TH and gene expression; Molecular readout of TH; TH and chromatin structure; Non-genomic effects of TH; Extra-cellular binding to integrins; TH metabolism

Tissue Engineering: the Science, the Technology and the Industry - (Henry Stewart Talks)

Historical perspective; Biomedical devices and diagnostics industry; Medical implant industry; Approved tissue products; Dermagraft; Tissue engineered skin substitutes; Cell source; Matrix; Immune tolerance; Embryonic stem cells

Tissue Factor and Factor VII: Initiation of Blood Coagulation - (Henry Stewart Talks)

Tissue factor and factor VII; Initiation of blood coagulation; Vertebrate blood coagulation; The resting state; The procoagulant response; The anticoagulant response; Molecular pathology; Tissue factor; Factor VII; Tissue factor pathway inhibitor

Titin I27: A Protein with a Complex Folding Landscape - (Henry Stewart Talks)

"Examination of the folding of titin 127; Evolution of the protein to withstand stress from mutation, the environment and to withstand mechanical force in the muscle"

Towards a unifying mechanism for the Hsp70 chaperones - (Henry Stewart Talks)

"Hsp70s are conserved molecular chaperones; They can prevent protein aggregation, they actively unfold and solubilize aggregates and pull translocating proteins across membranes"

TRAIL-Induced Apoptosis: From Analysis of the Death-Inducing Signalling Complex (DISC) to Clinical Applicability - (Henry Stewart Talks)

poptosis induction by the TNF-related apoptosis-inducing ligand (TRAIL); Apoptosis-inducing TNF super-family ligands and receptors; Formation of deathinducing signalling complex (DISC); Caspase-8 versus caspase-10; Synergy of TRAIL with chemotherapeutics

Transcription Activation - (Henry Stewart Talks)

Transcription by RNA polymerase II; Mediator complex; Coactivator proteins; Communication between DNA-binding proteins and general transcription machinery

Transcription Elongation Control by RNA Polymerase II - (Henry Stewart Talks)

Transcriptional elongation; Complexes involved; Mechanisms regulating rate and efficiency of elongation on chromatin templates

Transcription Factor NF-Kappa B - (Henry Stewart Talks)

NF-kappa B activation and function; Signal transduction pathway; Mechanism of post-transcriptional induction; Gene activation; Role of NF-kappa B in physiological processes; Initiation of the immune system; Cell survival

Transgenic mouse models of prion diseases - (Henry Stewart Talks)

"Prions represent a new biological paradigm of protein-mediated information transfer; Prions are the cause of fatal, transmissible neurodegenerative diseases, often referred to as transmissible spongiform encephalopathies (TSEs)"

Translocation: movement of tRNA and mRNA through the ribosome - (Henry Stewart Talks)

"Ribosomes and translation; Molecular composition of the ribosome; Why is the ribosome so big?; The mRNA channel in the 30S subunit; Positions of tRNA in the A-, P- and E-sites; Structural dynamics of the ribosome during translocation"

Treatment of stroke: specific management - thromboylsis plus - (Henry Stewart Talks)

Global stroke burden; Neurological symptoms; Where do thromboembolic occlusions originate?; Recanalization; Pharmacological treatment; Clinical trials; Treatment indications for intravenous rt-PA; Common misunderstandings

Two-stage genome-wide association designs - (Henry Stewart Talks)

"Introduction to genome-wide association studies (GWAs); Construction, analysis and power of two-stage GWAs; Designing optimal two-stage GWAs; Strategies for further reducing the cost of two-stage GWAs; Handling custom arrays when designing optimal GWA"

Type I Interferon System and Viruses - (Henry Stewart Talks)

"Type I IFN, a cytokine with antiviral activity; General mechanism of action of type I IFN; The IFN pathway|Induction of IFN and inhibition by viruses; Cellular sensors of viral products; Signaling pathway leading to type IFN production"