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Ubiquitin dependent degradation of proteins modified by oxidation, deamidation and glycation: role in vision - (Henry Stewart Talks)

Description of cataract and AMD as the ultimate protein misfolding diseases; Lens development: a model for aging research; Photo-oxidative stress to the retina; Etiology; Environmental factors; Pathophysiology; Protein quality control

Ubiquitination and Alzheimer Related Disorders - (Henry Stewart Talks)

Alzheimer's disease and dementia with Lewy bodies; Ubiquitin and the ubiquitin pathway of intracellular proteolysis; Ubiquitin immunocytochemistry in understanding chronic neurodegenerative disease; Ubiquitin and the discovery of dementia with Lewy bodies

Ubiquitin-Mediated Internalization and Degradation of PTK Receptors - (Henry Stewart Talks)

"Signal transduction by growth factor-activated protein tyrosine kinase receptors; Receptor endocytosis; The three vesicular sorting steps occurring at the plasma membrane, in endosomes and in a pre-lysosomal compartment"

UDP-glucurononsyltransferases - (Henry Stewart Talks)

The glucuronidation reaction; UGT enzyme superfamily; Importance for xenobiotic and drug metabolism; Substrate and inhibitor specificities; Gene regulation; Tissue specific expression; Genetic polymorphism; Structure/function relationships

UGT1A1 polymorphisms and irinotecan toxicity in colorectal cancer patients - (Henry Stewart Talks)

Irinotecan activity and safety; Metabolism of Irinotecan; Structure of UGT1A; Role of UGT1A1*28 on irinotecan pharmacogenetics; Role of UGT1A1*6 in Asians; Genotype-based dosing of irinotecan; Other candidates: UGT1A enzyme or transporter

Uncertainty in health economic evaluation - (Henry Stewart Talks)

Application of Bayesian methodology to health economics; The theory of cost-effectiveness and measures such as the incremental cost-effectiveness ratio and the incremental net benefit; Economic modeling

Understanding cancer trends - (Henry Stewart Talks)

"Current trends in cancer incidence, mortality and relative survival in the US; Understanding how improvements in prevention, early detection and treatment affect these trends"

Understanding Obesity: Genes and the Environment in the Determination of Body Weight - (Henry Stewart Talks)

Evolutionary arguments for regulation of body fat; Gene x gene x environment interactions; Molecular physiology of control of body weight; Human monogenic obesities; Complex genetics of human obesity; Threshold model for control of body weight

Understanding Protein Variability Through Functional Analysis of Random Mutagenesis - (Henry Stewart Talks)

Random mutagenesis; Strategies; Single template: oligonucleotide-based and PCRbased strategies; Recombination-based strategies; Bias; MAX codons; Random mutagenesis of an entire gene; Mutagenesis due to PCR error; Non-homologous recombination strategies

Update on the management of neuropathic pain in cancer patients - (Henry Stewart Talks)

Neuropathic pain; Epidemiology of neuropathic pain in cancer patients; Common neuropathic pain syndromes in cancer patients; Diagnosis of neuropathic pain in cancer patients; Treatment of neuropathic pain in cancer patients

Urgency of stroke prevention after TIA - (Henry Stewart Talks)

TIA definition; Short-term prognosis after TIA; Predicting risk; Unique pathophysiology; Distinguishing TIA from mimics; Urgent treatment

Use of Algorithms for High Quality Diagnostics and Handling of Patients with Autoimmune Rheumatic Diseases - (Henry Stewart Talks)

Tests to diagnose autoimmune rheumatic diseases; Parameters to indicate clinical value of test results; Tests based on different technologies; Making diagnostics clinically appropriate; Algorithms for use in family practice and in rheumatology practice

Use of computational chemistry and structures of ribosome complexes to design new antibiotics - (Henry Stewart Talks)

Many antibiotics inhibit the ribosome; Intelligent engine builds perpetual pipeline; Crystallography shows 50S is a target-of-targets; From new X-ray crystals to new leads; Analog(Trade Mark); LINKER essentials: tethering two binding features

Use of DNA Pooling in Large-Scale Association Studies - (Henry Stewart Talks)

Principles of DNA pooling; The cost benefit; Getting the quantification right; SNaPshot; Estimating and incorporating measurement error; Consequences of differential amplification; Pool construction vs. genotyping errors; Determining optimal design

Use of isolated populations: pitfalls and potential - (Henry Stewart Talks)

"Disease mutations in Finland; Molecular background of Finnish disease heritage; Finnish disease genes, novel pathways exposed; Example: APECED; AIRE protein; AIRE regulates ectopic expression in thymus; AIRE deficiency"

Using gene expression information to provide insights into patterning and differentiation - (Henry Stewart Talks)

Gastrulation; Dorsoventral patterning in the early embryo; Activation of signaling pathways; Control of cell movements and differentiation events; Mesoderm cell spreading and heart cell specification; FGF signaling during development