[URE3] and [PSI+] not found in wild strains indicating they are harmful; [Het-s] may benefit its host or may result from “meiotic drive”; Some “prion domains” cannot be prions; “Prion domains” have non-prion functions
The yeast plasmid as a highly optimized design for a multi-copy selfish DNA element; The need for an active partitioning system for the segregation of a high copy plasmid; Coupling between plasmid segregation and chromosome segregation
Role of protein chaperones in protein folding; Yeast prions as amyloid forms of cellular proteins; Requirement of chaperone machinery for prion propagation; Chaperone mutants adversely affect prions and provide insight into chaperone/amyloid interactions
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